Full Product Name
KLK5 Polyclonal Antibody
Product Synonym Names
KLK5
Product Gene Name
anti-KLK5 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 19; NC_000019.9 (51446559..51456344, complement). Location: 19q13.33
3D Structure
ModBase 3D Structure for Q53F68
Specificity
KLK5 [This rabbit antibody recognizes aa 280-293 of human KLK5 (also known as KLK-L2), one of the many kallikrein serine proteases associated with carcinogenesis.]
This antibody recognizes the gene product hk5 of human KLK5 (also known as KLK-L2), one of the many kallikrein serine proteases associated with carcinogenesis. KLK5 is upregulated by estrogens and progestins and is expressed in breast, brain, and testis.
Form/Format
100 ug affinity-purified antibody in PBS, pH 7.4.
Antigen
Peptide corresponding to aa 280-293 of human KLK5 protein.
Preservatives
0.02% sodium azide.
Dilutions Instructions
Dilute in PBS or medium which is identical to that used in the assay system.
Preparation and Storage
This antibody is stable for at least one (1) year at -70 degree C. Avoid multiple freeze thaw cycles.
Other Notes
Small volumes of anti-KLK5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-KLK5 antibody
Cancer Research Products
Applications Tested/Suitable for anti-KLK5 antibody
Immunoblot
Application Notes for anti-KLK5 antibody
Immunoblotting: use at 1:500-1:1,000 dilution. A band of approximately 32 kD is detected.
NCBI/Uniprot data below describe general gene information for KLK5. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001070960.1
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NCBI GenBank Nucleotide #
NM_001077492.1
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UniProt Primary Accession #
Q53F68
[Other Products]
UniProt Related Accession #
Q53F68; Q53ZR3; Q6S9W8; Q8IU55; Q9Y337[Other Products]
Molecular Weight
32,034 Da[Similar Products]
NCBI Official Full Name
kallikrein-5 preproprotein
NCBI Official Synonym Full Names
kallikrein-related peptidase 5
NCBI Official Symbol
KLK5??[Similar Products]
NCBI Official Synonym Symbols
SCTE; KLKL2; KLK-L2
??[Similar Products]
NCBI Protein Information
kallikrein-5; kallikrein 5; kallikrein-like protein 2; stratum corneum tryptic enzyme
UniProt Protein Name
Kallikrein 5 preproprotein variant
Protein Family
Kallikrein
UniProt Entry Name
Q53F68_HUMAN
NCBI Summary for KLK5
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its expression is up-regulated by estrogens and progestins. The encoded protein is secreted and may be involved in desquamation in the epidermis. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq]
UniProt Comments for KLK5
KLK5: May be involved in desquamation. Belongs to the peptidase S1 family. Kallikrein subfamily.
Protein type: Secreted; EC 3.4.21.-; Secreted, signal peptide; Protease
Chromosomal Location of Human Ortholog: 19q13.33
Cellular Component: extracellular space
Molecular Function: peptidase activity; protein binding; serine-type peptidase activity; serine-type endopeptidase activity
Biological Process: epidermis development; positive regulation of G-protein coupled receptor protein signaling pathway; proteolysis
Research Articles on KLK5
1. KLK5 may promote metastatic dissemination of OSCC by promoting loss of junctional integrity through cleavage of desmoglein 1.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
