PKD; PKCM; PRKCM; PKC-MU

For Research Use Only. Not for use in diagnostic procedures.

IgG

Rabbit

Affinity purification

Store at -20 degree C. Avoid freeze / thaw cycles.

Small volumes of anti-S744/748 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

PRKD1 is a serine/threonine kinase that regulates a variety of cellular functions, including membrane receptor signaling, transport at the Golgi, protection from oxidative stress at the mitochondria, gene transcription, and regulation of cell shape, motility, and adhesion (summary by Eiseler et al., 2009

Phosphorylated

Western Blot (WB)

WB: 1:500 - 1:2000

Calculated MW: 102kDa
Molecular Weight: 912

protein kinase D1

serine/threonine-protein kinase D1

Serine/threonine-protein kinase D1

PKD; PKD1; PRKCM??[Similar Products]

KPCD1_HUMAN

PRKD1 is a serine/threonine kinase that regulates a variety of cellular functions, including membrane receptor signaling, transport at the Golgi, protection from oxidative stress at the mitochondria, gene transcription, and regulation of cell shape, motility, and adhesion (summary by Eiseler et al., 2009 [PubMed 19329994]).[supplied by OMIM, Nov 2010]

PRKD1: a CAMK kinase of the PKD family. Cleavage by caspase-3 following DNA damage activates it and alters its subcellular localization. Sensitizes cells to apoptosis induced by genotoxic stress. Its cleavage is blocked in cells that over-express the anti-apoptotic Bcl-x(L) protein. Expression of a caspase-resistant mutant partially inhibits DNA damage-induced apoptosis. Its activation by TLR ligands is dependent on MyD88, IRAK4 and -1, but not TRAF6. Essential for MyD88-dependent proinflammatory immune responses. Activated by diacylglycerol and phorbol esters. Binds to the trans-Golgi network and regulates the fission of transport carriers specifically destined to the cell surface. Colocalizes with F-actin at peripheral F-actin-rich structures in membrane ruffles at the edge of lamellipodia in cervical carcinoma cells. Substrates reportedly include critical regulatory proteins including CREB, SSH1L, CTNNB1, HDACs 5 and 7, PKD1, HPK1, MARK2, PIP5K2A, PPP1R14A

Protein type: Autophagy; Protein kinase, CAMK; EC 2.7.11.13; Protein kinase, Ser/Thr (non-receptor); Motility/polarity/chemotaxis; Kinase, protein; CAMK group; PKD family

Chromosomal Location of Human Ortholog: 14q11

Cellular Component: cell cortex; cytoplasm; cytosol; Golgi apparatus; integral to plasma membrane; intercellular junction; nucleus; plasma membrane; trans-Golgi network

Molecular Function: ATP binding; identical protein binding; metal ion binding; protein binding; protein kinase C activity; protein serine/threonine kinase activity

Biological Process: activation of CREB transcription factor; activation of NF-kappaB transcription factor; angiogenesis; apoptosis; cell proliferation; Golgi organization and biogenesis; Golgi vesicle transport; inflammatory response; innate immune response; integrin-mediated signaling pathway; negative regulation of endocytosis; peptidyl-serine phosphorylation; positive regulation of angiogenesis; positive regulation of blood vessel endothelial cell migration; positive regulation of endothelial cell proliferation; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of osteoblast differentiation; positive regulation of peptidyl-serine phosphorylation; positive regulation of transcription from RNA polymerase II promoter; protein amino acid autophosphorylation; regulation of release of sequestered calcium ion into cytosol; signal transduction; sphingolipid biosynthetic process; sphingolipid metabolic process; vascular endothelial growth factor receptor signaling pathway

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