FSGS2; TRP6; Transient receptor protein 6

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit

200ug/ml (lot specific)

Manufactured in an ISO 9001:2008 and ISO 13485:2003 Certified Laboratory.

Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customera??s specifications, please inquire.

Small volumes of anti-TRPC6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Western Blot (WB), Immunohistochemistry (IHC)

100,106 Da

transient receptor potential cation channel subfamily C member 6

short transient receptor potential channel 6

Short transient receptor potential channel 6

TRP-6??[Similar Products]

The protein encoded by this gene forms a receptor-activated calcium channel in the cell membrane. The channel is activated by diacylglycerol and is thought to be under the control of a phosphatidylinositol second messenger system. Activation of this channel occurs independently of protein kinase C and is not triggered by low levels of intracellular calcium. Defects in this gene are a cause of focal segmental glomerulosclerosis 2 (FSGS2). [provided by RefSeq, Mar 2009]

TRPC6: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C. Seems not to be activated by intracellular calcium store depletion. Interacts with MX1 and RNF24. Expressed primarily in placenta, lung, spleen, ovary and small intestine. Expressed in podocytes and is a component of the glomerular slit diaphragm. Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC6 sub-subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Channel, cation; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 11q22.1

Cellular Component: cytoplasm; integral component of plasma membrane; membrane; plasma membrane

Molecular Function: actin binding; actinin binding; ATPase binding; calcium channel activity; cation channel activity; clathrin binding; inositol 1,4,5 trisphosphate binding; protein binding; protein homodimerization activity; store-operated calcium channel activity

Biological Process: aging; cation transport; cellular response to hydrogen peroxide; cellular response to hypoxia; elevation of cytosolic calcium ion concentration; manganese ion transport; negative regulation of dendrite morphogenesis; neuron differentiation; platelet activation; positive regulation of calcium ion transport; positive regulation of ion transmembrane transporter activity; positive regulation of neuron differentiation; positive regulation of peptidyl-threonine phosphorylation; regulation of cytosolic calcium ion concentration; single fertilization

Disease: Focal Segmental Glomerulosclerosis 2

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