Full Product Name
TRPC6 antibody
Product Gene Name
anti-TRPC6 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q61143
Species Reactivity
Human, Mouse, Rat
Specificity
TRPC6 antibody detects endogenous levels of total TRPC6 protein.
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Form/Format
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Immunogen
The antiserum was produced against a synthesized peptide Corresponding to the amino terminal sequence from mouse TRPC6 protein ("RRNESQDYLLMDELG").
Preparation and Storage
Store at-20 degree C for 1 year
Other Notes
Small volumes of anti-TRPC6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-TRPC6 antibody
Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
Applications Tested/Suitable for anti-TRPC6 antibody
Western Blot (WB)
Application Notes for anti-TRPC6 antibody
WB: 1:500-1:1000
Western Blot (WB) of anti-TRPC6 antibody
Western blot analysis using TRPC6 antibody Lane 1 human A549 cells Lane2 mouse brain Lane3 rat brain
NCBI/Uniprot data below describe general gene information for TRPC6. It may not necessarily be applicable to this product.
NCBI Accession #
NP_038866.2
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NCBI GenBank Nucleotide #
NM_013838.2
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UniProt Primary Accession #
Q61143
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UniProt Secondary Accession #
Q9Z2J1; B9EIW2[Other Products]
UniProt Related Accession #
Q61143[Other Products]
Molecular Weight
106,681 Da
NCBI Official Full Name
short transient receptor potential channel 6 isoform 1
NCBI Official Synonym Full Names
transient receptor potential cation channel, subfamily C, member 6
NCBI Official Symbol
Trpc6??[Similar Products]
NCBI Official Synonym Symbols
TRP-6; Trrp6; mtrp6; AV025995; LLHWJM002; LLHWJM003; LLHWJM004
??[Similar Products]
NCBI Protein Information
short transient receptor potential channel 6
UniProt Protein Name
Short transient receptor potential channel 6
UniProt Synonym Protein Names
Calcium entry channel; Transient receptor protein 6; TRP-6
Protein Family
Short transient receptor potential channel
UniProt Gene Name
Trpc6??[Similar Products]
UniProt Synonym Gene Names
TRP-6??[Similar Products]
UniProt Comments for TRPC6
Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C. Seems not to be activated by intracellular calcium store depletion.
Product References and Citations for anti-TRPC6 antibody
Koichiro Kuwahara et al. (2006) J Clin Invest. 116(12): 3114-3126. Mark Estacion et al. (2006) J Physiol. 2006, 572(Pt 2): 359-377. Maria A et al. (2006) Proc Natl Acad Sci U S A. 103(44): 16586-16591.
Research Articles on TRPC6
1. Administration of soluble klotho significantly reduced obstruction-induced renal fibrosis in wild-type mice, but not in Trpc6 knockout mice, indicating that klotho and TRPC6 inhibition act in the same pathway to protect against obstruction-induced renal fibrosis.
Precautions
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Disclaimer
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