Product Name
Bruton agammaglobulinemia tyrosine kinase (BTK), Polyclonal Antibody
Full Product Name
Rabbit anti-human Bruton agammaglobulinemia tyrosine kinase polyclonal Antibody
Product Synonym Names
Bruton agammaglobulinemia tyrosine kinase; BTK; AGMX1; AT; ATK; BPK; IMD1; MGC126261; MGC126262; PSCTK1; XLA
Product Gene Name
anti-BTK antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen Affinity Purified
Storage Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-1108 / sc-1107 / sc-1696
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-BTK antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-BTK antibody
ELISA (EIA), Western Blot (WB)
NCBI/Uniprot data below describe general gene information for BTK. It may not necessarily be applicable to this product.
NCBI Accession #
AAB60639.1
[Other Products]
UniProt Secondary Accession #
Q32ML5; B2RAW1[Other Products]
UniProt Related Accession #
Q06187[Other Products]
Molecular Weight
79,937 Da[Similar Products]
NCBI Official Full Name
Bruton agammaglobulinemia tyrosine kinase
NCBI Official Synonym Full Names
Bruton agammaglobulinemia tyrosine kinase
NCBI Official Symbol
BTK??[Similar Products]
NCBI Official Synonym Symbols
AT; ATK; BPK; XLA; IMD1; AGMX1; PSCTK1
??[Similar Products]
NCBI Protein Information
tyrosine-protein kinase BTK; B-cell progenitor kinase; agammaglobulinaemia tyrosine kinase; truncated Bruton agammaglobulinemia tyrosine kinase; tyrosine-protein kinase BTK isoform (lacking exon 14); dominant-negative kinase-deficient Brutons tyrosine kinase
UniProt Protein Name
Tyrosine-protein kinase BTK
UniProt Synonym Protein Names
Agammaglobulinemia tyrosine kinase; ATK; B-cell progenitor kinase; BPK; Bruton tyrosine kinase
Protein Family
Tyrosine-protein kinase
UniProt Gene Name
BTK??[Similar Products]
UniProt Synonym Gene Names
AGMX1; ATK; BPK; ATK; BPK??[Similar Products]
UniProt Entry Name
BTK_HUMAN
NCBI Summary for BTK
The protein encoded by this gene plays a crucial role in B-cell development. Mutations in this gene cause X-linked agammaglobulinemia type 1, which is an immunodeficiency characterized by the failure to produce mature B lymphocytes, and associated with a failure of Ig heavy chain rearrangement. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2013]
UniProt Comments for BTK
Btk: a tyrosine kinase of the Tec family. Plays a crucial role in B-cell ontogeny. Defects cause X-linked agammaglobulinemia, an immunodeficiency characterized by failure to produce mature B lymphocyte cells and associated with a failure of Ig heavy chain rearrangement. Truncated splice forms found in childhood leukemias may underlie radiation resistance of tumors through inhibition of apoptosis.
Protein type: Protein kinase, tyrosine (non-receptor); Protein kinase, TK; EC 2.7.10.2; Kinase, protein; TK group; Tec family
Chromosomal Location of Human Ortholog: Xq21.33-q22
Cellular Component: extrinsic to internal side of plasma membrane; mast cell granule; intracellular membrane-bound organelle; perinuclear region of cytoplasm; cytoplasm; plasma membrane; cytoplasmic vesicle; cytosol; nucleus; lipid raft
Molecular Function: identical protein binding; protein binding; phosphatidylinositol-3,4,5-triphosphate binding; metal ion binding; protein-tyrosine kinase activity; non-membrane spanning protein tyrosine kinase activity; ATP binding; receptor binding
Biological Process: I-kappaB kinase/NF-kappaB cascade; adaptive immune response; B cell activation; transcription, DNA-dependent; cell maturation; calcium-mediated signaling; protein amino acid phosphorylation; T cell receptor signaling pathway; regulation of cell proliferation; activation of NF-kappaB transcription factor; toll-like receptor 2 signaling pathway; regulation of B cell cytokine production; MyD88-dependent toll-like receptor signaling pathway; regulation of B cell apoptosis; B cell receptor signaling pathway; histamine secretion by mast cell; toll-like receptor signaling pathway; positive regulation of B cell differentiation; innate immune response; mesoderm development; cell differentiation; toll-like receptor 4 signaling pathway; transmembrane receptor protein tyrosine kinase signaling pathway
Disease: Agammaglobulinemia, X-linked; Isolated Growth Hormone Deficiency, Type Iii
Research Articles on BTK
1. We observed that Nef interacts with the Tec family members Bmx, Btk, and Itk but not Tec or Txk.
Precautions
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Disclaimer
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