Leucine zipper-like transcription regulator 1

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit

Affinity chromatography purified via peptide column

Supplied in PBS containing 0.02% sodium azide.

Can be stored at -20 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Small volumes of anti-LZTR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

LZTR1, a member of the BTB-kelch superfamily, was initially described as a putative transcriptional regulator based on weak homology to members of the basic leucine zipper-like family, the encoded protein subsequently has been shown to localize exclusively to the Golgi network where it may help stabilize the Golgi complex. Deletion of this gene may be associated with DiGeorge syndrome, a developmental field defect involving the third and fourth pharyngeal pouches, causing the absence of thymus and parathyroid glands, congenital cardiac abnormalities and facial dysmorphism. LZTR1 is tyrosine phosphorylated and subsequently degraded upon induction of apoptosis.

Total protein Ab

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

Western blot analysis of LZTR1 in human heart tissue lysate with LZTR1 antibody at (A) 1 and (B) 2 ug/mL.

Immunohistochemistry of LZTR1 in mouse heart tissue with LZTR1 antibody at 5 ug/mL.

94,719 Da

Leucine-zipper-like transcriptional regulator 1

TCFL2; LZTR-1??[Similar Products]

LZTR1_HUMAN

LZTR1: Probable transcriptional regulator that may play a crucial role in embryogenesis.

Protein type: Transcription factor; EC 3.4.22.-

Chromosomal Location of Human Ortholog: 22q11.21|22q11.1-q11.2

Molecular Function: transcription factor activity

Biological Process: anatomical structure morphogenesis; regulation of transcription, DNA-dependent

Disease: Schwannomatosis 2

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