Full Product Name
LZTR1 antibody - C-terminal region
Product Gene Name
anti-LZTR1 antibody
[Similar Products]
Product Synonym Gene Name
LZTR-1[Similar Products]
Antibody/Peptide Pairs
LZTR1 peptide (MBS3229279) is used for blocking the activity of LZTR1 antibody (MBS3204312)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
Synthetic peptide located within the following region: GFYNNRLQAY CKQNLEMNVT VQNVLQILEA ADKTQALDMK RHCLHIIVHQ
3D Structure
ModBase 3D Structure for Q8N653
Species Reactivity
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
Purity/Purification
Protein A purified
Form/Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Homology
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 93%
Immunogen
The immunogen is a synthetic peptide directed towards the C terminal region of human LZTR1
Preparation and Storage
For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Other Notes
Small volumes of anti-LZTR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-LZTR1 antibody
This is a rabbit polyclonal antibody against LZTR1. It was validated on Western Blot using a cell lysate as a positive control.
Target Description: Leucine-zipper-like transcriptional regulator 1(LZTR1) is belived to be a DNA-binding protein and transcriptional regulator based on its predicted structural characteristics. The transcript is present in several essential fetal organs and is hemizygously deleted in some DiGeorge syndrome patients. LZTR1 is thought to play a critical role in embryogenesis.Leucine-zipper-like transcriptional regulator 1 is belived to be a DNA-binding protein and transcriptional regulator based on its predicted structural characteristics. The transcript is present in several essential fetal organs and is hemizygously deleted in some DiGeorge syndrome patients. It is thought to play a critical role in embryogenesis.
Product Categories/Family for anti-LZTR1 antibody
Polyclonal; Transcription Regulation; Developmental Biology; Disease Related; DNA/RNA/Protein Interactions; Transcription Factors;
Applications Tested/Suitable for anti-LZTR1 antibody
Western Blot (WB)
Western Blot (WB) of anti-LZTR1 antibody
WB Suggested Anti-LZTR1 Antibody Titration: 2.5ug/ml
ELISA Titer: 1:312500
Positive Control: Jurkat cell lysate
NCBI/Uniprot data below describe general gene information for LZTR1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_006758
[Other Products]
NCBI GenBank Nucleotide #
NM_006767
[Other Products]
UniProt Primary Accession #
Q8N653
[Other Products]
UniProt Related Accession #
Q8N653[Other Products]
NCBI Official Full Name
leucine-zipper-like transcriptional regulator 1
NCBI Official Synonym Full Names
leucine zipper like transcription regulator 1
NCBI Official Symbol
LZTR1??[Similar Products]
NCBI Official Synonym Symbols
NS2; NS10; BTBD29; LZTR-1; SWNTS2
??[Similar Products]
NCBI Protein Information
leucine-zipper-like transcriptional regulator 1
UniProt Protein Name
Leucine-zipper-like transcriptional regulator 1
Protein Family
Leucine-zipper-like transcriptional regulator
UniProt Gene Name
LZTR1??[Similar Products]
UniProt Synonym Gene Names
TCFL2; LZTR-1??[Similar Products]
UniProt Entry Name
LZTR1_HUMAN
NCBI Summary for LZTR1
This gene encodes a member of the BTB-kelch superfamily. Initially described as a putative transcriptional regulator based on weak homology to members of the basic leucine zipper-like family, the encoded protein subsequently has been shown to localize exclusively to the Golgi network where it may help stabilize the Gogli complex. Deletion of this gene may be associated with DiGeorge syndrome. [provided by RefSeq, Jul 2008]
UniProt Comments for LZTR1
LZTR1: Probable transcriptional regulator that may play a crucial role in embryogenesis.
Protein type: EC 3.4.22.-; Transcription factor
Chromosomal Location of Human Ortholog: 22q11.21|22q11.1-q11.2
Molecular Function: transcription factor activity
Biological Process: anatomical structure morphogenesis; regulation of transcription, DNA-dependent
Disease: Schwannomatosis 2
Research Articles on LZTR1
1. LZTR1 mutation is associated with Noonan syndrome.
Precautions
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Disclaimer
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