Full Product Name
LITAF Antibody
Product Synonym Names
PIG7; SIMPLE; TP53I7
Product Gene Name
anti-LITAF antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q99732
Species Reactivity
Human, Mouse, Rat
Specificity
LITAF Antibody detects endogenous levels of total LITAF
Purity/Purification
Immunogen affinity purified
Form/Format
In phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Immunogen
Recombinant protein of human LITAF
Preparation and Storage
Store at-20 degree C for 1 year
Other Notes
Small volumes of anti-LITAF antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-LITAF antibody
Lipopolysaccharide is a potent stimulator of monocytes and macrophages, causing secretion of tumor necrosis factor-alpha (TNF-alpha) and other inflammatory mediators. This gene encodes lipopolysaccharide-induced TNF-alpha factor, which is a DNA-binding protein and can mediate the TNF-alpha expression by direct binding to the promoter region of the TNF-alpha gene. The transcription of this gene is induced by tumor suppresor p53 and has been implicated in the p53-induced apoptotic pathway. Mutations in this gene cause Charcot-Marie-Tooth disease type 1C (CMT1C) and may be involved in the carcinogenesis of extramammary Paget's disease (EMPD). Multiple alternatively spliced transcript variants have been found for this gene.
Applications Tested/Suitable for anti-LITAF antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-LITAF antibody
WB: 1:500-1:2000
IHC: 1:50-1:200
Western Blot (WB) of anti-LITAF antibody
Western blot analysis of extracts of various celllines, using LITAF antibody.
NCBI/Uniprot data below describe general gene information for LITAF. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001129944.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001136472.1
[Other Products]
UniProt Primary Accession #
Q99732
[Other Products]
UniProt Secondary Accession #
Q05DW0; Q9C0L6; D3DUG1; G5E9K0[Other Products]
UniProt Related Accession #
Q99732[Other Products]
NCBI Official Full Name
lipopolysaccharide-induced tumor necrosis factor-alpha factor isoform 1
NCBI Official Synonym Full Names
lipopolysaccharide induced TNF factor
NCBI Official Symbol
LITAF??[Similar Products]
NCBI Official Synonym Symbols
PIG7; SIMPLE; TP53I7
??[Similar Products]
NCBI Protein Information
lipopolysaccharide-induced tumor necrosis factor-alpha factor
UniProt Protein Name
Lipopolysaccharide-induced tumor necrosis factor-alpha factor
UniProt Synonym Protein Names
Small integral membrane protein of lysosome/late endosome
Protein Family
Lipopolysaccharide-induced tumor necrosis factor-alpha factor
UniProt Gene Name
LITAF??[Similar Products]
UniProt Synonym Gene Names
; LPS-induced TNF-alpha factor??[Similar Products]
NCBI Summary for LITAF
Lipopolysaccharide is a potent stimulator of monocytes and macrophages, causing secretion of tumor necrosis factor-alpha (TNF-alpha) and other inflammatory mediators. This gene encodes lipopolysaccharide-induced TNF-alpha factor, which is a DNA-binding protein and can mediate the TNF-alpha expression by direct binding to the promoter region of the TNF-alpha gene. The transcription of this gene is induced by tumor suppressor p53 and has been implicated in the p53-induced apoptotic pathway. Mutations in this gene cause Charcot-Marie-Tooth disease type 1C (CMT1C) and may be involved in the carcinogenesis of extramammary Paget's disease (EMPD). Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2014]
UniProt Comments for LITAF
Plays a role in endosomal protein trafficking and in targeting proteins for lysosomal degradation (PubMed:23166352). Plays a role in targeting endocytosed EGFR and ERGG3 for lysosomal degradation, and thereby helps downregulate downstream signaling cascades (PubMed:23166352). Helps recruit the ESCRT complex components TSG101, HGS and STAM to cytoplasmic membranes (PubMed:23166352). Probably plays a role in regulating protein degradation via its interaction with NEDD4 (PubMed:15776429). May also contribute to the regulation of gene expression in the nucleus (PubMed:10200294, PubMed:15793005). Binds DNA (in vitro) and may play a synergistic role with STAT6 in the nucleus in regulating the expression of various cytokines (PubMed:15793005). May regulate the expression of numerous cytokines, such as TNF, CCL2, CCL5, CXCL1, IL1A and IL10 (PubMed:10200294, PubMed:15793005).
Research Articles on LITAF
1. our findings provide a novel apoptotic regulatory pathway in which LITAF, as a transcription factor, inhibits the expression of BCL6, which leads to activation of the intrinsic mitochondrial pathway and tumor apoptosis.
Precautions
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Disclaimer
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