BTR1; CDPD; CHED2; NABC1; SLC4A11; solute carrier family 4, sodium borate

For Research Use Only. Not for use in diagnostic procedures.

SLC4A11 antibody detects endogenous levels of total SLC4A11 protein.

Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Store at-20 degree C for 1 year.

Small volumes of anti-SLC4A11 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells

Western Blot (WB), ELISA (EIA)

WB: 1:500~1:1000
ELISA: 1:20000

Western blot analysis of extracts from 3T3 cells, RAW264.7 cells and A549 cells, using SLC4A11 antibody.

103,145 Da

solute carrier family 4 member 11

sodium bicarbonate transporter-like protein 11

Sodium bicarbonate transporter-like protein 11

BTR1; NaBC1??[Similar Products]

This gene encodes a voltage-regulated, electrogenic sodium-coupled borate cotransporter that is essential for borate homeostasis, cell growth and cell proliferation. Mutations in this gene have been associated with a number of endothelial corneal dystrophies including recessive corneal endothelial dystrophy 2, corneal dystrophy and perceptive deafness, and Fuchs endothelial corneal dystrophy. Multiple transcript variants encoding different isoforms have been described. [provided by RefSeq, Mar 2010]

Transporter which plays an important role in sodium-mediated fluid transport in different organs. Prevents severe morphological changes of the cornea caused by increased sodium chloride concentrations in the stroma. In the inner ear, is involved in transport of potassium through the fibrocyte layer to the stria vascularis and is essential for the generation of the endocochlear potential but not for regulation of potassium concentrations in the endolymph. In the kidney, is essential for urinary concentration, mediates a sodium flux into the thin descending limb of Henle loop to allow countercurrent multiplication by osmotic equilibration (). Involved in borate homeostasis. In the absence of borate, it functions as a Na+ and OH-(H+) channel. In the presence of borate functions as an electrogenic Na+ coupled borate cotransporter.

Parker M.D., Biochem. Biophys. Res. Commun. 282:1103-1109(2001). Deloukas P., Nature 414:865-871(2001). Ota T., Nat. Genet. 36:40-45(2004).

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