CCL4; ACT2; G-26; HC21; LAG1; LAG-1; MIP1B; SCYA2; SCYA4; MIP1B1; AT744.1; MIP-1-beta; C-C motif chemokine 4; G-26 T-lymphocyte-secreted protein; chemokine (C-C motif) ligand 4

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

CCL4 Antibody is affinity chromatography purified via peptide column.

Liquid

1 mg/mL (lot specific)

CCL4 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year.

Small volumes of anti-CCL4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

CCL4 Antibody: CCL4, also known as macrophage inflammatory protein 1-beta (MIP1B), belongs to the intercrine beta (chemokine CC) family. Both CCL4 and the related protein CCL3 participate in the host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups of inflammatory cells. While both CCL4 and CCL3 exert similar effects on monocytes, their effect on lymphocytes differ; with CCL4 selectively attracting CD4+ lymphocytes and CCL3 selectively attracting CD8+ lymphocytes. Additionally, both have been shown to be potent chemoattractants for B cells, eosinophils and dendritic cells. The processed form of CCL4 can induce down-modulation of surface expression of the chemokine receptor CCR5, thus inhibiting the CCR5-mediated entry of HIV-1 in T cells.

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

CCL4 antibody can be used for detection of CCL4 by Western blot at 1 - 2 ug/mL.
Optimal dilutions for each application to be determined by the researcher.

Western blot analysis of CCL4 in rat brain tissue lysate with CCL4 antibody at 1 μg/mL.

Immunohistochemistry of CCL4 in rat brain tissue with CCL4 antibody at 2.5 μg/ml.

Immunofluorescence of CCL4 in rat brain tissue with CCL4 antibody at 20 μg/ml.

Predicted: 10 kDa

chemokine (C-C motif) ligand 4

C-C motif chemokine 4; PAT 744; SIS-gamma; MIP-1-beta(1-69); secreted protein G-26; T-cell activation protein 2; G-26 T-lymphocyte-secreted protein; lymphocyte activation gene 1 protein; macrophage inflammatory protein 1-beta; small inducible cytokine A4 (homologous to mouse Mip-1b)

C-C motif chemokine 4

LAG1; MIP1B; SCYA4; LAG-1; MIP-1-beta; ACT-2??[Similar Products]

CCL4_HUMAN

The protein encoded by this gene is a mitogen-inducible monokine and is one of the major HIV-suppressive factors produced by CD8+ T-cells. The encoded protein is secreted and has chemokinetic and inflammatory functions. [provided by RefSeq, Dec 2012]

CCL4: Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5- mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B. Belongs to the intercrine beta (chemokine CC) family.

Protein type: Chemokine; Motility/polarity/chemotaxis; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 17q12

Cellular Component: extracellular space; extracellular region

Molecular Function: identical protein binding; protein binding; CCR1 chemokine receptor binding; chemokine activity; cytokine activity; CCR5 chemokine receptor binding

Biological Process: cell-cell signaling; response to virus; response to toxin; establishment and/or maintenance of cell polarity; immune response; positive regulation of calcium-mediated signaling; cell adhesion; signal transduction; inflammatory response; positive regulation of calcium ion transport; cell motility

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