ACT2; G-26; HC21; LAG1; LAG-1; MIP1B; SCYA2; SCYA4; MIP1B1; AT744.1; MIP-1-beta; C-C motif chemokine 4; G-26 T-lymphocyte-secreted protein; chemokine (C-C motif) ligand 4

For Research Use Only. Not for use in diagnostic procedures.

Liquid

200 ug/mL (lot specific)

Store CCL4 peptide at -20 degree C, stable for one year.

Small volumes of CCL4 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Blocking (BL)

CCL4 peptide is used for blocking the activity of CCL4 antibody.

10,212 Da

chemokine (C-C motif) ligand 4

C-C motif chemokine 4; PAT 744; SIS-gamma; MIP-1-beta(1-69); secreted protein G-26; T-cell activation protein 2; G-26 T-lymphocyte-secreted protein; lymphocyte activation gene 1 protein; macrophage inflammatory protein 1-beta; small inducible cytokine A4 (homologous to mouse Mip-1b)

C-C motif chemokine 4

LAG1; MIP1B; SCYA4; LAG-1; MIP-1-beta; ACT-2??[Similar Products]

CCL4_HUMAN

The protein encoded by this gene is a mitogen-inducible monokine and is one of the major HIV-suppressive factors produced by CD8+ T-cells. The encoded protein is secreted and has chemokinetic and inflammatory functions. [provided by RefSeq, Dec 2012]

CCL4: Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5- mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B. Belongs to the intercrine beta (chemokine CC) family.

Protein type: Secreted, signal peptide; Motility/polarity/chemotaxis; Chemokine; Secreted

Chromosomal Location of Human Ortholog: 17q12

Cellular Component: extracellular space; extracellular region

Molecular Function: identical protein binding; CCR1 chemokine receptor binding; protein binding; chemokine activity; cytokine activity; CCR5 chemokine receptor binding

Biological Process: cell-cell signaling; response to virus; response to toxin; establishment and/or maintenance of cell polarity; immune response; positive regulation of calcium-mediated signaling; positive regulation of calcium ion transport; cell adhesion; inflammatory response; signal transduction; cell motility

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