Mouse Sodium bicarbonate transporter-like protein 11 (SLC4A11) ELISA kit; RP4-794I6.3; BTR1; CDPD; CDPD1; CHED2; MGC126418; MGC126419; NABC1; dJ794I6.2; bicarbonate transporter related protein 1; sodium-coupled borate cotransporter 1; solute carrier family 4 member 11; solut; solute carrier family 4; sodium borate transporter; member 11

For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C

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Small volumes of SLC4A11 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9334886 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the solute carrier family 4, sodium borate transporter, member 11 (SLC4A11) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing SLC4A11. The ELISA analytical biochemical technique of the MBS9334886 kit is based on SLC4A11 antibody-SLC4A11 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect SLC4A11 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, SLC4A11. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

96,751 Da

solute carrier family 4, sodium bicarbonate transporter-like, member 11

sodium bicarbonate transporter-like protein 11; Sodium borate cotransporter 1; Solute carrier family 4 member 11; bicarbonate transporter-related protein 1

Sodium bicarbonate transporter-like protein 11

BTR1; NaBC1??[Similar Products]

S4A11_MOUSE

SLC4A11: Transporter which plays an important role in sodium- mediated fluid transport in different organs. Prevents severe morphological changes of the cornea caused by increased sodium chloride concentrations in the stroma. In the inner ear, is involved in transport of potassium through the fibrocyte layer to the stria vascularis and is essential for the generation of the endocochlear potential but not for regulation of potassium concentrations in the endolymph. In the kidney, is essential for urinary concentration, mediates a sodium flux into the thin descending limb of Henle loop to allow countercurrent multiplication by osmotic equilibration. Involved in borate homeostasis. In the absence of borate, it functions as a Na(+) and OH(-)(H(+)) channel. In the presence of borate functions as an electrogenic Na(+) coupled borate cotransporter. Defects in SLC4A11 are the cause of corneal dystrophy and perceptive deafness (CDPD); also known as corneal dystrophy and sensorineural deafness or Harboyan syndrome. CDPD consists of congenital corneal endothelial dystrophy and progressive perceptive deafness. Inheritance is autosomal recessive. Defects in SLC4A11 are the cause of corneal endothelial dystrophy type 2 (CHED2); also known as congenital hereditary endothelial dystrophy of cornea. This bilateral corneal dystrophy is characterized by corneal opacification and nystagmus. Inheritance is autosomal recessive. Defects in SLC4A11 are the cause of corneal dystrophy Fuchs endothelial type 4 (FECD4); also known as Corneal dystrophy Fuchs endothelial late-onset. It is an ocular disorder caused by loss of endothelium of the central cornea. It is characterized by focal wart-like guttata that arise from Descemet membrane and develop in the central cornea, epithelial blisters, reduced vision and pain. Descemet membrane is thickened by abnormal collagenous deposition. Belongs to the anion exchanger (TC 2.A.31) family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Membrane protein, integral

Cellular Component: membrane; integral to plasma membrane; cell; plasma membrane; integral to membrane

Molecular Function: protein dimerization activity; bicarbonate transmembrane transporter activity; transporter activity; inorganic anion exchanger activity; anion:anion antiporter activity; symporter activity; boron transporter activity; anion transmembrane transporter activity; hydrogen ion channel activity; sodium channel activity

Biological Process: proton transport; cellular cation homeostasis; fluid transport; transport; ion homeostasis; inorganic anion transport; bicarbonate transport; sodium ion transport; regulation of intracellular pH; ion transport; anion transport; boron transport

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