Anti -USP26, CT (Ubiquitin Carboxyl-terminal Hydrolase 26, Ubiquitin Thiolesterase 26, Ubiquitin-specific processing Protease 26, Deubiquitinating Enzyme 26)

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: X; NC_000023.10 (132159507..132162300, complement). Location: Xq26.2

Polyclonal

IgG

Rabbit

Recognizes human USP26.

Affinity Purified
Purified by Protein G affinity chromatography.

Supplied as a liquid in PBS, 0.09% sodium azide.

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Small volumes of anti-USP26 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Modification of target proteins by ubiquitin participates in a wide array of biological functions. Proteins destined for degradation or processing via the 26 S proteasome are coupled to multiple copies of ubiquitin. However, attachment of ubiquitin or ubiquitin-related molecules may also result in changes in subcellular distribution or modification of protein activity. An additional level of ubiquitin regulation, deubiquitination, is catalyzed by proteases called deubiquitinating enzymes, which fall into four distinct families. Ubiquitin C-terminal hydrolases, ubiquitin-specific processing proteases (USPs),1 OTU-domain ubiquitin-aldehyde-binding proteins, and Jab1/Pad1/MPN-domain-containing metallo-enzymes. Among these four families, USPs represent the most widespread and represented deubiquitinating enzymes across evolution. USPs tend to release ubiquitin from a conjugated protein. They display similar catalytic domains containing conserved Cys and His boxes but divergent N-terminal and occasionally C-terminal extensions, which are thought to function in substrate recognition, subcellular localization, and protein-protein interactions.

Antibodies; Abs to Ubiquitin

ELISA (EL/EIA), Immunohistochemistry (IHC)

Suitable for use in ELISA and Immunohistochemistry.
Dilution: ELISA: 1:1,000
Immunohistochemistry: 1:50-1:100

103,998 Da[Similar Products]

ubiquitin specific peptidase 26

ubiquitin carboxyl-terminal hydrolase 26; OTTHUMP00000024046; ubiquitin thioesterase 26; deubiquitinating enzyme 26; ubiquitin thiolesterase 26; ubiquitin specific protease 26; ubiquitin-specific processing protease 26; ubiquitin-specific-processing protease 26

Ubiquitin carboxyl-terminal hydrolase

Q495F8_HUMAN

This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases and is a deubiquitinating enzyme (DUB) with His and Cys domains. It is specifically expressed in testis tissue. Mutations in this gene have been associated with Sertoli cell-only syndrome and male infertility. [provided by RefSeq]

USP26: Involved in the ubiquitin-dependent proteolytic pathway in conjunction with the 26S proteasome. Deubiquitinates the androgen receptor and regulates the androgen receptor signaling pathway. Belongs to the peptidase C19 family.

Protein type: Ubiquitin conjugating system; Ubiquitin-specific protease; Protease; EC 3.4.19.12

Chromosomal Location of Human Ortholog: Xq26.2

Cellular Component: nucleus

Molecular Function: protein binding; cysteine-type endopeptidase activity; ubiquitin-specific protease activity

Biological Process: proteasomal ubiquitin-dependent protein catabolic process; protein deubiquitination

Disease: Spermatogenic Failure, X-linked, 1

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