Full Product Name
DCLRE1C Antibody
Product Gene Name
anti-DCLRE1C antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q96SD1
Other Notes
Small volumes of anti-DCLRE1C antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for DCLRE1C. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001029027.1
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NCBI GenBank Nucleotide #
NM_001033855.2
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UniProt Primary Accession #
Q96SD1
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UniProt Secondary Accession #
Q1HCL2; Q5JSR4; Q5JSR5; Q5JSR7; Q5JSR8; Q5JSR9; Q5JSS0; Q5JSS7; Q6PK14; Q8N101; D3DRT6[Other Products]
UniProt Related Accession #
Q96SD1[Other Products]
Molecular Weight
49,944 Da
NCBI Official Full Name
protein artemis isoform a
NCBI Official Synonym Full Names
DNA cross-link repair 1C
NCBI Official Symbol
DCLRE1C??[Similar Products]
NCBI Official Synonym Symbols
SCIDA; SNM1C; A-SCID; RS-SCID; DCLREC1C
??[Similar Products]
NCBI Protein Information
protein artemis
UniProt Protein Name
Protein artemis
UniProt Synonym Protein Names
DNA cross-link repair 1C protein; Protein A-SCID; SNM1 homolog C; hSNM1C; SNM1-like protein
Protein Family
Protein artemis
UniProt Gene Name
DCLRE1C??[Similar Products]
UniProt Synonym Gene Names
ARTEMIS; ASCID; SCIDA; SNM1C; hSNM1C??[Similar Products]
NCBI Summary for DCLRE1C
This gene encodes a nuclear protein that is involved in V(D)J recombination and DNA repair. The encoded protein has single-strand-specific 5'-3' exonuclease activity; it also exhibits endonuclease activity on 5' and 3' overhangs and hairpins. The protein also functions in the regulation of the cell cycle in response to DNA damage. Mutations in this gene can cause Athabascan-type severe combined immunodeficiency (SCIDA) and Omenn syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
UniProt Comments for DCLRE1C
Required for V(D)J recombination, the process by which exons encoding the antigen-binding domains of immunoglobulins and T-cell receptor proteins are assembled from individual V, (D), and J gene segments. V(D)J recombination is initiated by the lymphoid specific RAG endonuclease complex, which generates site specific DNA double strand breaks (DSBs). These DSBs present two types of DNA end structures: hairpin sealed coding ends and phosphorylated blunt signal ends. These ends are independently repaired by the non homologous end joining (NHEJ) pathway to form coding and signal joints respectively. This protein exhibits single-strand specific 5'-3' exonuclease activity in isolation and acquires endonucleolytic activity on 5' and 3' hairpins and overhangs when in a complex with PRKDC. The latter activity is required specifically for the resolution of closed hairpins prior to the formation of the coding joint. May also be required for the repair of complex DSBs induced by ionizing radiation, which require substantial end-processing prior to religation by NHEJ.
Research Articles on DCLRE1C
1. Data suggest that stimulation of Artemis nuclease/DCLRE1C activity by XRCC4-DNA ligase IV hetero-complex and efficiency of blunt-end ligation are determined by structural configurations at the DNA ends. (XRCC4 = X-ray repair cross complementing 4)
Precautions
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Disclaimer
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