Full Product Name
CCL4 Antibody
Product Synonym Names
ACT2; G-26; HC21; LAG1; LAG-1; MIP1B; SCYA2; SCYA4; MIP1B1; AT744.1; MIP-1-beta
Product Gene Name
anti-CCL4 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P13236
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Affinity purification
Immunogen
A synthetic peptide of human CCL4
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Preparation and Storage
Store at-20 degree C or-80 degree C. Avoid freeze/thaw cycles.
Other Notes
Small volumes of anti-CCL4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CCL4 antibody
Chemokines are members of a superfamily of small inducible, secreted, pro-inflammatory cytokines. Members of the chemokine family exhibit 20 to 50% homology in their predicted amino acid sequences and are divided into four subfamilies. In C-C (or b) subfamily, the first two cysteines are adjacent. C-C chemokines are chemoattractants and activators for monocytes and T cells. C-C subfamily members include macrophage inflammatory protein (MIP)-1?, MIP-1?, MIP-2, MIP-3?, MIP-3?, MIP-4, HCC-1, MIP-5 (or HCC-2), RANTES, MCP-1/2/3 (and the murine homologs JE and MARC), I-309, murine C10 and TCA3. Research has shown that MIP-1? is more selective than MIP-1?, primarily attracting CD4+ T lymphocytes, with a preference for T cells of the naive phenotype. MIP-1? is a more potent lymphocyte chemoattractant than MIP-1? and exhibits a broader range of chemoattractant specificities. It has been suggested that CD8+ T lymphocytes are involved in the control of HIV infection in vivo by the release of HIV-suppressive factors (HIV-SF). MIP-1? has been identified as one of the major HIV-SFs produced by CD8+ T cells, along with MIP-1? and RANTES. Recombinant human MIP-1? acts as an inhibitor of different strains of HIV-1, HIV-2 and SIV infection in a dose-dependent manner.
Product Categories/Family for anti-CCL4 antibody
Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
Applications Tested/Suitable for anti-CCL4 antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-CCL4 antibody
WB: 1:500-1:2000
IHC: 1:50-1:200
Testing Data of anti-CCL4 antibody
Western blot analysis of extracts of SGC7901cell lines, using CCL4 antibody.
NCBI/Uniprot data below describe general gene information for CCL4. It may not necessarily be applicable to this product.
NCBI Accession #
NP_002975.1
[Other Products]
NCBI GenBank Nucleotide #
NM_002984.3
[Other Products]
UniProt Primary Accession #
P13236
[Other Products]
UniProt Secondary Accession #
P22617; Q13704; Q3SXL8; Q6FGI8[Other Products]
UniProt Related Accession #
P13236[Other Products]
NCBI Official Full Name
C-C motif chemokine 4
NCBI Official Synonym Full Names
C-C motif chemokine ligand 4
NCBI Official Symbol
CCL4??[Similar Products]
NCBI Official Synonym Symbols
ACT2; G-26; HC21; LAG1; LAG-1; MIP1B; SCYA2; SCYA4; MIP1B1; AT744.1; MIP-1-beta
??[Similar Products]
NCBI Protein Information
C-C motif chemokine 4
UniProt Protein Name
C-C motif chemokine 4
UniProt Synonym Protein Names
G-26 T-lymphocyte-secreted protein; HC21; Lymphocyte activation gene 1 protein; LAG-1
Protein Family
C-C motif chemokine
UniProt Gene Name
CCL4??[Similar Products]
UniProt Synonym Gene Names
LAG1; MIP1B; SCYA4; LAG-1; MIP-1-beta; ACT-2??[Similar Products]
NCBI Summary for CCL4
The protein encoded by this gene is a mitogen-inducible monokine and is one of the major HIV-suppressive factors produced by CD8+ T-cells. The encoded protein is secreted and has chemokinetic and inflammatory functions. [provided by RefSeq, Dec 2012]
UniProt Comments for CCL4
Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5-mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B.
Research Articles on CCL4
1. We found that the A/G homozygotes of CCL4 rs10491121 polymorphism reduced the risks for Hepatocellular carcinoma (HCC). The present report is the first time to examine the risk factors associated with CCL4 SNPs in HCC progression in Taiwan.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
