Ubiquitin carboxyl-terminal hydrolase 26; Deubiquitinating enzyme 26; Ubiquitin thioesterase 26; Ubiquitin-specific-processing protease 26; USP26

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

Antigen Affinity Purified

Liquid; PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Small volumes of anti-USP26 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Involved in the ubiquitin-dependent proteolytic pathway in conjunction with the 26S proteasome (By similarity). Deubiquitinates the androgen receptor and regulates the androgen receptor signaling pathway.

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200

Western blot
All lanes: USP26 antibody at 5.22ug/ml
Lane 1: Hela whole cell lysate
Lane 2: U937 whole cell lysate
Lane 3: Mouse gonadal tissue
Lane 4: Mouse liver tissue
Secondary
Goat polyclonal to Rabbit IgG at 1/10000 dilution
Predicted band size: 105 kDa
Observed band size: 105 kDa

Immunohistochemistry of paraffin-embedded human liver tissue using MBS7044323 at dilution 1:100

Immunohistochemistry of paraffin-embedded human small intestine tissue using MBS7044323 at dilution 1:100

ubiquitin specific peptidase 26

ubiquitin carboxyl-terminal hydrolase 26

Ubiquitin carboxyl-terminal hydrolase 26

UBP26_HUMAN

This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases and is a deubiquitinating enzyme (DUB) with His and Cys domains. It is specifically expressed in testis tissue. Mutations in this gene have been associated with Sertoli cell-only syndrome and male infertility. [provided by RefSeq, Jul 2008]

USP26: Involved in the ubiquitin-dependent proteolytic pathway in conjunction with the 26S proteasome. Deubiquitinates the androgen receptor and regulates the androgen receptor signaling pathway. Belongs to the peptidase C19 family.

Protein type: Protease; EC 3.4.19.12; Ubiquitin conjugating system; Ubiquitin-specific protease

Chromosomal Location of Human Ortholog: Xq26.2

Cellular Component: nucleus

Molecular Function: protein binding

Biological Process: protein deubiquitination

Disease: Spermatogenic Failure, X-linked, 1

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