Serotonin N-acetyltransferase; Serotonin acetylase; Aralkylamine N-acetyltransferase; AA-NAT; Aanat; Snat; 2.3.1.87

For Research Use Only. Not for use in diagnostic procedures.

Store at 4 degree C

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Small volumes of Aanat elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9427933 is a ready-to-use microwell, strip-or-full plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Serotonin N-acetyltransferase (Aanat) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing Aanat. The ELISA analytical biochemical technique of the MBS9427933 kit is based on Aanat antibody-Aanat antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect Aanat antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, Aanat. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

23,142 Da

aralkylamine N-acetyltransferase

serotonin N-acetyltransferase

Serotonin N-acetyltransferase

Snat; Serotonin acetylase; AA-NAT??[Similar Products]

The protein encoded by this gene belongs to the acetyltransferase superfamily. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for the function of the circadian clock that influences activity and sleep. This enzyme is regulated by cAMP-dependent phosphorylation that promotes its interaction with 14-3-3 proteins and thus protects the enzyme against proteasomal degradation. This gene may contribute to numerous genetic diseases such as delayed sleep phase syndrome. [provided by RefSeq, Feb 2014]

AA-NAT: Catalyzes the N-acetylation of serotonin into N- acetylserotonin. Controls the night/day rhythm of melatonin production in the pineal gland. Has a relative affinity for hydroxylated versus non-hydroxylated arylalkylamines. Belongs to the acetyltransferase family. AANAT subfamily. Monomer. Interacts with YWHAZ; the interaction requires phosphorylation on Thr-31, and modulates the enzymatic activity of AANAT through preventing dephosphorylation and/or proteolysis and stabilizing substrate binding. Subsequently, a second molecule of AANAT can bind, via the phosphorylated Ser-205 site, the other YWHAZ monomer with similar effect.

Protein type: Acetyltransferase; Amino Acid Metabolism - tryptophan; EC 2.3.1.87

Chromosomal Location of Human Ortholog: 10q32.2

Cellular Component: cytoplasm; cytosol; perinuclear region of cytoplasm

Molecular Function: aralkylamine N-acetyltransferase activity; arylamine N-acetyltransferase activity

Biological Process: circadian rhythm; entrainment of circadian clock by photoperiod; melatonin biosynthetic process; N-terminal protein amino acid acetylation; photoperiodism; response to calcium ion; response to cAMP; response to copper ion; response to corticosterone stimulus; response to cytokine stimulus; response to insulin stimulus; response to light stimulus; response to organic cyclic substance; response to zinc ion

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