Full Product Name
Anti-ALK Rabbit pAb
Product Synonym Names
ALK tyrosine kinase receptor; Nucleophosmin; NPM1; ALK
Product Gene Name
anti-ALK antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P06748
Species Reactivity
Human, Mouse, Rat
Specificity
ALK Antibody detects endogenous levels of total ALK
Purity/Purification
Affinity Chromatography
Form/Format
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Immunogen
A synthesized peptide derived from human ALK
Preparation and Storage
Store at 4 degree C for short term.
Store at-20 degree C for long term.
Avoid freeze/thaw cycle.
Other Notes
Small volumes of anti-ALK antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ALK antibody
Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids.
Applications Tested/Suitable for anti-ALK antibody
Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF)
Application Notes for anti-ALK antibody
IHC: 1:100-1:500
ICC/IF: 1:50-1:100
Immunohistochemistry (IHC) of anti-ALK antibody
Immunohistochemical analysis of paraffin-embedded human kidney, using ALK Antibody.
NCBI/Uniprot data below describe general gene information for ALK. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001032827.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001037738.2
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UniProt Primary Accession #
P06748
[Other Products]
UniProt Secondary Accession #
P08693; Q12826; Q13440; Q13441; Q14115; Q5EU94; Q5EU95; Q5EU96; A8K3N7; B5BU00; D3DQL6[Other Products]
UniProt Related Accession #
P06748[Other Products]
Molecular Weight
28,400 Da
NCBI Official Full Name
nucleophosmin isoform 3
NCBI Official Synonym Full Names
nucleophosmin 1
NCBI Official Symbol
NPM1??[Similar Products]
NCBI Official Synonym Symbols
B23; NPM
??[Similar Products]
NCBI Protein Information
nucleophosmin
UniProt Protein Name
Nucleophosmin
UniProt Synonym Protein Names
Nucleolar phosphoprotein B23; Nucleolar protein NO38; Numatrin
Protein Family
Alkylsulfatase
UniProt Gene Name
NPM1??[Similar Products]
UniProt Synonym Gene Names
NPM; NPM??[Similar Products]
NCBI Summary for ALK
The protein encoded by this gene is involved in several cellular processes, including centrosome duplication, protein chaperoning, and cell proliferation. The encoded phosphoprotein shuttles between the nucleolus, nucleus, and cytoplasm, chaperoning ribosomal proteins and core histones from the nucleus to the cytoplasm. This protein is also known to sequester the tumor suppressor ARF in the nucleolus, protecting it from degradation until it is needed. Mutations in this gene are associated with acute myeloid leukemia. Dozens of pseudogenes of this gene have been identified. [provided by RefSeq, Aug 2017]
UniProt Comments for ALK
Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication. Negatively regulates the activation of EIF2AK2/PKR and suppresses apoptosis through inhibition of EIF2AK2/PKR autophosphorylation. Antagonizes the inhibitory effect of ATF5 on cell proliferation and relieves ATF5-induced G2/M blockade (PubMed:22528486). In complex with MYC enhances the transcription of MYC target genes (PubMed:25956029).
Research Articles on ALK
1. Data suggest that the direct interaction of several regions of nucleophosmin 1 (NPM1) C-terminal domain (CTD) with cellular membranes could be implicated in diseases where NPM1 is mutated and/or where its overexpression is cytoxic.
Precautions
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