Product Name
Ankyrin repeat and SOCS box protein 2 (Asb2), Recombinant Protein
Full Product Name
Recombinant Mouse Ankyrin repeat and SOCS box protein 2 (Asb2)
Product Gene Name
Asb2 recombinant protein
[Similar Products]
Product Synonym Gene Name
Asb2[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
1-634aa, full length protein
Sequence
MATEISTRGR QRAIGHEEYS LYSSLSEEEL LQMAIEQSLA DKTRGPTPAE ASASSQTNHQ PGHFHPWTRS PSSPENPPAR APLGLFQGVM QKYSSNLFKT SQMAAMDPVL KAIKEGDEEA LKIMIQDGKN LAEPNKEGWL PLHEAAYYGQ LGCLKVLQQA YPGTIDQRTL QEETALYLAT CREHLDCLLS LLQAGAEPDI SNKSRETPLY KACERKNAEA VRILVRYNAD ANHRCNRGWT ALHESVSRND LEVMEILVSG GAKVEAKNVY SITPLFVAAQ SGQLEALRFL AKHGADINTQ ASDSASALYE ASKNEHEDVV EFLLSQGADA NKANKDGLLP LHVASKKGNY RIVQMLLPVT SRTRVRRSGI SPLHLAAERN HDAVLEALLA ARFDVNAPLA PERARLYEDR RSSALYFAVV NNNVYATELL LLAGADPNRD VISPLLVAIR HGCLRTMQLL LDHGANIDAY IATHPTAFPA TIMFAMKCLS LLKFLMDLGC DGEPCFSCLY GNGPHPPAPR PGRFHDAPVD DKAPSVVQFC EFLSAPEVSR WAGPIIDVLL DYVGNVQLCS RLKEHIDSFE DWAVIKEKAE PPRPLAHLCR LRVRKAIGKY RIKLLDTLPL PGRLIRYLKY ENTQ
3D Structure
ModBase 3D Structure for Q8K0L0
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of Asb2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
Asb2 recombinant protein
This protein is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. This gene is induced by all-trans retinoic acid. In myeloid leukemia cells, the expression of this encoded protein has been shown to induce growth inhibition and chromatin condensation. Multiple alternatively spliced transcript variants have been described for this gene but their full length sequences are not known.
NCBI/Uniprot data below describe general gene information for Asb2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_075536.1
[Other Products]
NCBI GenBank Nucleotide #
NM_023049.1
[Other Products]
UniProt Primary Accession #
Q8K0L0
[Other Products]
UniProt Secondary Accession #
Q9CTH4; Q9WV73[Other Products]
UniProt Related Accession #
Q8K0L0[Other Products]
Molecular Weight
64,937 Da
NCBI Official Full Name
ankyrin repeat and SOCS box protein 2
NCBI Official Synonym Full Names
ankyrin repeat and SOCS box-containing 2
NCBI Official Symbol
Asb2??[Similar Products]
NCBI Official Synonym Symbols
1110008E15Rik
??[Similar Products]
NCBI Protein Information
ankyrin repeat and SOCS box protein 2
UniProt Protein Name
Ankyrin repeat and SOCS box protein 2
Protein Family
Anthranilate synthase
UniProt Gene Name
Asb2??[Similar Products]
UniProt Synonym Gene Names
ASB-2??[Similar Products]
UniProt Comments for Asb2
Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Research Articles on Asb2
1. This study identifies desmin as a new Asb2b target for proteasomal degradation in cardiomyocytes and suggests that accumulation of desmin could contribute to UPS impairment in Hypertrophic cardiomyopathy mice and patients
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
