Product Name
Dihydropteridine reductase (Qdpr), Recombinant Protein
Full Product Name
Recombinant Mouse Dihydropteridine reductase (Qdpr)
Product Gene Name
Qdpr recombinant protein
[Similar Products]
Product Synonym Gene Name
Qdpr[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
1-241aa, full length protein
Sequence
MAASGEARRV LVYGGRGALG SRCVQAFRAR NWWVASIDVV ENEEASASVV VKMTDSFTEQ ADQVTADVGK LLGDQKVDAI LCVAGGWAGG NAKSKSLFKN CDMMWKQSMW TSTISSHLAT KHLKEGGLLT LAGAKAALDG TPGMIGYGMA KGAVHQLCQS LAGKNSGMPP GAAAIAVLPV TLDTPMNRKS MPEADFSSWT PLEFLVETFH DWITGNKRPN SGSLIQVVTT DGKTELTPAY F
3D Structure
ModBase 3D Structure for Q8BVI4
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of Qdpr recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
Qdpr recombinant protein
This gene encodes the enzyme dihydropteridine reductase, which catalyzes the NADH-mediated reduction of quinonoid dihydrobiopterin. This enzyme is an essential component of the pterin-dependent aromatic amino acid hydroxylating systems. Mutations in this gene resulting in QDPR deficiency include aberrant splicing, amino acid substitutions, insertions, or premature terminations. Dihydropteridine reductase deficiency presents as atypical phenylketonuria due to insufficient production of biopterin, a cofactor for phenylalanine hydroxylase.
NCBI/Uniprot data below describe general gene information for Qdpr. It may not necessarily be applicable to this product.
NCBI Accession #
NP_077198.1
[Other Products]
NCBI GenBank Nucleotide #
NM_024236.2
[Other Products]
UniProt Primary Accession #
Q8BVI4
[Other Products]
UniProt Secondary Accession #
Q3TT09; Q9D0K4[Other Products]
UniProt Related Accession #
Q8BVI4[Other Products]
Molecular Weight
25,570 Da
NCBI Official Full Name
dihydropteridine reductase
NCBI Official Synonym Full Names
quinoid dihydropteridine reductase
NCBI Official Symbol
Qdpr??[Similar Products]
NCBI Official Synonym Symbols
Dhpr; PKU2; D5Ertd371e; 2610008L04Rik
??[Similar Products]
NCBI Protein Information
dihydropteridine reductase
UniProt Protein Name
Dihydropteridine reductase
UniProt Synonym Protein Names
HDHPR; Quinoid dihydropteridine reductase
Protein Family
Dihydropteridine reductase
UniProt Gene Name
Qdpr??[Similar Products]
UniProt Synonym Gene Names
Dhpr??[Similar Products]
UniProt Comments for Qdpr
The product of this enzyme, tetrahydrobiopterin (BH-4), is an essential cofactor for phenylalanine, tyrosine, and tryptophan hydroxylases.
Research Articles on Qdpr
1. wide alterations in folate-associated metabolism in the Qdpr(-/-) mice
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
