For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 21; NC_000021.8 (37832919..37948867, complement). Location: 21q22.3

Highly Purified
Highly Purified

Supplied as a lyophilized powder in PBS.

May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Small volumes of CLDN14 peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

C-SATHSGYRLNDYV, C Terminus

Molecular Biology; MB-Claudin

ELISA (EL/EIA)

Suitable for use in Peptide ELISA.

25,699 Da[Similar Products]

claudin 14

claudin-14

Claudin-14

CLD14_HUMAN

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. The encoded protein also binds specifically to the WW domain of Yes-associated protein. Defects in this gene are the cause of an autosomal recessive form of nonsyndromic sensorineural deafness. It is also reported that four synonymous variants in this gene are associated with kidney stones and reduced bone mineral density. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2010]

Function: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity

By similarity.

Subcellular location: Cell junction ? tight junction. Cell membrane; Multi-pass membrane protein.

Tissue specificity: Liver, kidney. Also found in ear.

Involvement in disease: Deafness, autosomal recessive, 29 (DFNB29) [MIM:614035]: A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.2 Ref.8 Ref.10

Sequence similarities: Belongs to the claudin family.

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