CLDN14

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

Purified by Epitope Affinity Purification

Supplied in sterile Phosphate buffered saline (pH7.2) containing antibody stabilizer.

The antibodies are stable for 12 months from date of receipt when stored at -20 degree C. The antibodies can be stored at 2 degree C - 8 degree C for one month without detectable loss of activity. Avoid repeated freezing-thawing cycles.

Small volumes of anti-CLDN14 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

N/A

Immunohistochemistry (IHC), Western Blot (WB)

Immunohistochemistry: 2-10 ug/ml
Western Blot: 0.1-1 ug/ml

25,699 Da[Similar Products]

claudin 14

claudin-14

Claudin-14

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. The encoded protein also binds specifically to the WW domain of Yes-associated protein. Defects in this gene are the cause of an autosomal recessive form of nonsyndromic sensorineural deafness. It is also reported that four synonymous variants in this gene are associated with kidney stones and reduced bone mineral density. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2010]

Claudin-14: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity. Defects in CLDN14 are the cause of deafness autosomal recessive type 29 (DFNB29). DFNB29 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. Belongs to the claudin family.

Protein type: Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 21q22.13

Cellular Component: endoplasmic reticulum; plasma membrane; tight junction

Molecular Function: identical protein binding

Biological Process: calcium-independent cell-cell adhesion; protein complex assembly

Disease: Deafness, Autosomal Recessive 29

Wilcox, E.R., et al Mutations in the gene encoding tight junction claudin-14 cause autosomal recessive deafness DFNB29. Cell 104 (1), 165-172 (2001)

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