Full Product Name
QDPR Antibody
Product Synonym Names
DHPR; PKU2; SDR33C1
Product Gene Name
anti-QDPR antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P09417
Specificity
The antibody detects endogenous levels of total QDPR protein.
Purity/Purification
Antigen Affinity Purification
Form/Format
Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
Concentration
1 mg/ml (lot specific)
Immunogen
Fusion protein of human QDPR
Preparation and Storage
Store at -20 degree C
Other Notes
Small volumes of anti-QDPR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-QDPR antibody
This gene encodes the enzyme dihydropteridine reductase, which catalyzes the NADH-mediated reduction of quinonoid dihydrobiopterin. This enzyme is an essential component of the pterin-dependent aromatic amino acid hydroxylating systems. Mutations in this gene resulting in QDPR deficiency include aberrant splicing, amino acid substitutions, insertions, or premature terminations. Dihydropteridine reductase deficiency presents as atypical phenylketonuria due to insufficient production of biopterin, a cofactor for phenylalanine hydroxylase.
Product Categories/Family for anti-QDPR antibody
Total protein Ab
Applications Tested/Suitable for anti-QDPR antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-QDPR antibody
Western Blot: 1:500-1:2000
Immunohistochemistry: 1:25-1:100
Western Blot (WB) of anti-QDPR antibody
Gel: 12%SDS-PAGE Lysate: 40 μ g Lane 1-3: K562, hepg2, Jurkat cell Primary antibody: 1/400 dilution Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution Exposure time: 30 seconds
Immunohistochemistry (IHC) of anti-QDPR antibody
Immunohistochemical analysis of paraffin-embedded Human prostate cancer tissue using at dilution 1/20. (Original magnification: ??200)
NCBI/Uniprot data below describe general gene information for QDPR. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000311.2
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NCBI GenBank Nucleotide #
NM_000320.2
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UniProt Primary Accession #
P09417
[Other Products]
UniProt Secondary Accession #
Q53F52; Q9H3M5; A8K158; B3KW71[Other Products]
UniProt Related Accession #
P09417[Other Products]
Molecular Weight
22,408 Da
NCBI Official Full Name
dihydropteridine reductase isoform 1
NCBI Official Synonym Full Names
quinoid dihydropteridine reductase
NCBI Official Symbol
QDPR??[Similar Products]
NCBI Official Synonym Symbols
DHPR; PKU2; SDR33C1
??[Similar Products]
NCBI Protein Information
dihydropteridine reductase
UniProt Protein Name
Dihydropteridine reductase
UniProt Synonym Protein Names
HDHPR; Quinoid dihydropteridine reductase; Short chain dehydrogenase/reductase family 33C member 1
Protein Family
Dihydropteridine reductase
UniProt Gene Name
QDPR??[Similar Products]
UniProt Synonym Gene Names
DHPR; SDR33C1??[Similar Products]
UniProt Entry Name
DHPR_HUMAN
UniProt Comments for QDPR
QDPR: The product of this enzyme, tetrahydrobiopterin (BH-4), is an essential cofactor for phenylalanine, tyrosine, and tryptophan hydroxylases. Defects in QDPR are the cause of BH4-deficient hyperphenylalaninemia type C (HPABH4C); also called dihydropteridine reductase deficiency (DHPR deficiency) or hyperphenylalaninemia tetrahydrobiopterin-deficient due to DHPR deficiency or quinoid dihydropteridine reductase deficiency (QDPR deficiency). HPABH4C is a rare autosomal recessive disorder characterized by hyperphenylalaninemia and severe neurologic symptoms (malignant hyperphenylalaninemia) including axial hypotonia and truncal hypertonia, abnormal thermogenesis, and microcephaly. These signs are attributable to depletion of the neurotransmitters dopamine and serotonin, whose syntheses are controlled by tryptophan and tyrosine hydroxylases that use BH-4 as cofactor. These patients do not respond to phenylalanine- restricted diet. HPABH4C is lethal if untreated. Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein type: Cofactor and Vitamin Metabolism - folate biosynthesis; EC 1.5.1.34; Oxidoreductase
Chromosomal Location of Human Ortholog: 4p15.31
Cellular Component: cytoplasm; cytosol
Molecular Function: 6,7-dihydropteridine reductase activity; electron carrier activity
Biological Process: amino acid metabolic process; dihydrobiopterin metabolic process; L-phenylalanine catabolic process
Disease: Hyperphenylalaninemia, Bh4-deficient, C
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