Full Product Name
QDPR Antibody
Product Synonym Names
DHPR; FLJ42391; PKU2; SDR33C1
Product Gene Name
anti-QDPR antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P09417
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Affinity purification
Immunogen
Recombinant protein of human QDPR
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Preparation and Storage
Store at-20 degree C or-80 degree C. Avoid freeze/thaw cycles.
Other Notes
Small volumes of anti-QDPR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-QDPR antibody
Dihydropteridine reductase (QDPR), also named as DHPR and HDHPR, is an essential enzyme in the hydroxylating system of the aromatic amino acids, since it catalyses the regeneration of tetrahydrobiopterin (BH4), the natural cofactor of phenylalanine, tyrosine, and tryptophan hydroxylases, from the quininoid-dihydrobiopterin produced in these coupled reactions(PMID:8326489). The QDPR protein is active as a dimer, with a subunit Mr of 26 kDa(PMID:7627180). This protein belongs to the short-chain dehydrogenases/reductases (SDR) family. Defects in QDPR are the cause of BH4-deficient hyperphenylalaninemia type C (HPABH4C)(PMID:11153907). This antibody is specific to QDPR.
Product Categories/Family for anti-QDPR antibody
Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
Applications Tested/Suitable for anti-QDPR antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-QDPR antibody
WB: 1:500-1:1000
IHC: 1:50-1:100
Western Blot (WB) of anti-QDPR antibody
Western blot analysis of extracts of mouse livertissue, using QDPR antibody.
NCBI/Uniprot data below describe general gene information for QDPR. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000311.2
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NCBI GenBank Nucleotide #
NM_000320.2
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UniProt Primary Accession #
P09417
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UniProt Secondary Accession #
Q53F52; Q9H3M5; A8K158; B3KW71[Other Products]
UniProt Related Accession #
P09417[Other Products]
NCBI Official Full Name
dihydropteridine reductase isoform 1
NCBI Official Synonym Full Names
quinoid dihydropteridine reductase
NCBI Official Symbol
QDPR??[Similar Products]
NCBI Official Synonym Symbols
DHPR; PKU2; SDR33C1
??[Similar Products]
NCBI Protein Information
dihydropteridine reductase
UniProt Protein Name
Dihydropteridine reductase
UniProt Synonym Protein Names
HDHPR; Quinoid dihydropteridine reductase; Short chain dehydrogenase/reductase family 33C member 1
Protein Family
Dihydropteridine reductase
UniProt Gene Name
QDPR??[Similar Products]
UniProt Synonym Gene Names
DHPR; SDR33C1??[Similar Products]
NCBI Summary for QDPR
This gene encodes the enzyme dihydropteridine reductase, which catalyzes the NADH-mediated reduction of quinonoid dihydrobiopterin. This enzyme is an essential component of the pterin-dependent aromatic amino acid hydroxylating systems. Mutations in this gene resulting in QDPR deficiency include aberrant splicing, amino acid substitutions, insertions, or premature terminations. Dihydropteridine reductase deficiency presents as atypical phenylketonuria due to insufficient production of biopterin, a cofactor for phenylalanine hydroxylase. [provided by RefSeq, Jul 2008]
UniProt Comments for QDPR
The product of this enzyme, tetrahydrobiopterin (BH-4), is an essential cofactor for phenylalanine, tyrosine, and tryptophan hydroxylases.
Research Articles on QDPR
1. Mutation of dihydropteridine reductase (QDPR) inhibited the regulation of TOR serine-threonine kinases (mTOR), suggesting that QDPR is a positive regulator of autophagy via suppressing mTOR signaling.
Precautions
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Disclaimer
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