Product Name
DPAGT1, cDNA Clone
Full Product Name
DPAGT1 cDNA Clone
Product Gene Name
DPAGT1 cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atgtgggcct tctcggaatt gcccatgccg ctgctgatca atttgatcgt ctcgctgctg ggatttgtgg ccacagtcac cctcatcccg gccttccggg gccacttcat tgctgcgcgc ctctgtggtc aggacctcaa caaaaccagc cgacagcaga tcccagaatc ccagggagtg atcagcggtg ctgttttcct tatcatcctc ttctgcttca tccctttccc cttcctgaac tgctttgtga aggagcagtg taaggcattc ccccaccatg aatttgtggc cctgataggt gccctccttg ccatctgctg catgatcttc ctgggctttg cggatgatgt actgaatctg cgctggcgcc ataagctgct gctacctaca gctgcctcac tacctctcct catggtctat ttcaccaact ttggcaacac gaccattgtg gtgcccaagc ccttccgccc gatacttggc ctgcatctgg acttgggaat cctgtactat gtctacatgg ggctgctggc agtgttctgt accaatgcca tcaatatcct agcaggaatt aacggcctag aggctggcca gtcactagtc atttctgctt ccatcattgt cttcaacctg gtagagttgg aaggtgattg tcgggatgat catgtctttt ccctctactt catgataccc ttttttttca ccactttggg attgctctac cacaactggt acccatcacg ggtgtttgtg ggagatacct tctgttactt tgctggcatg acctttgccg tggtgggcat cttgggacac ttcagcaaga ccatgctact attcttcatg ccccaggtgt tcaacttcct ctactcactg cctcagctcc tgcatatcat cccctgccct cgccaccgca tacccagact caatatcaag acaggcaaac tggagatgag ctattccaag ttcaagacca agagcctctc tttcttgggc acctttattt taaaggtggc agagagcctc cagctggtga cagtacacca gagtgagact gaagatggtg aattcactga atgtaacaac atgaccctca tcaacttgct acttaaagtc cttgggccca tacatgagag aaacctcaca ttgctcctgc tgctgctgca gatcctgggc agtgccatca ccttctccat tcgatatcag ctcgttcgac tcttctatga tgtctga
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of DPAGT1 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for DPAGT1. It may not necessarily be applicable to this product.
NCBI Accession #
BC000325
[Other Products]
UniProt Secondary Accession #
O15216; Q86WV9; Q9BWE6[Other Products]
UniProt Related Accession #
Q9H3H5[Other Products]
Molecular Weight
34,270 Da
NCBI Official Full Name
Homo sapiens dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase), mRNA
NCBI Official Synonym Full Names
dolichyl-phosphate N-acetylglucosaminephosphotransferase 1
NCBI Official Symbol
DPAGT1??[Similar Products]
NCBI Official Synonym Symbols
GPT; ALG7; DGPT; G1PT; UAGT; UGAT; CDG1J; CMS13; DPAGT; CDG-Ij; CMSTA2; DPAGT2; D11S366
??[Similar Products]
NCBI Protein Information
UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase
UniProt Protein Name
UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase
UniProt Synonym Protein Names
GlcNAc-1-P transferase; G1PT; GPT; N-acetylglucosamine-1-phosphate transferase
Protein Family
UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase
UniProt Gene Name
DPAGT1??[Similar Products]
UniProt Synonym Gene Names
DPAGT2; G1PT; GPT??[Similar Products]
UniProt Entry Name
GPT_HUMAN
NCBI Summary for DPAGT1
The protein encoded by this gene is an enzyme that catalyzes the first step in the dolichol-linked oligosaccharide pathway for glycoprotein biosynthesis. This enzyme belongs to the glycosyltransferase family 4. This protein is an integral membrane protein of the endoplasmic reticulum. The congenital disorder of glycosylation type Ij is caused by mutation in the gene encoding this enzyme. [provided by RefSeq, Jul 2008]
UniProt Comments for DPAGT1
DPAGT1: Catalyzes the initial step in the synthesis of dolichol- P-P-oligosaccharides. Defects in DPAGT1 are the cause of congenital disorder of glycosylation type 1J (CDG1J). CDGs are a family of severe inherited diseases caused by a defect in protein N- glycosylation. They are characterized by under-glycosylated serum proteins. These multisystem disorders present with a wide variety of clinical features, such as disorders of the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions. Belongs to the glycosyltransferase 4 family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Glycan Metabolism - N-glycan biosynthesis; Membrane protein, integral; Membrane protein, multi-pass; EC 2.7.8.15; Endoplasmic reticulum; Transferase
Chromosomal Location of Human Ortholog: 11q23.3
Cellular Component: endoplasmic reticulum membrane; integral to endoplasmic reticulum membrane; integral to membrane; intracellular membrane-bound organelle; membrane
Molecular Function: UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity; UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity
Biological Process: dolichol biosynthetic process; dolichol-linked oligosaccharide biosynthetic process; protein amino acid N-linked glycosylation; protein oligomerization; UDP-N-acetylglucosamine metabolic process
Disease: Congenital Disorder Of Glycosylation, Type Ij; Myasthenic Syndrome, Congenital, With Tubular Aggregates 2
Research Articles on DPAGT1
1. Data suggest that N-acetylglucosaminyl 1-phosphate transferase is a breast cancer therapeutic target.
Precautions
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Disclaimer
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