Product Name
MATN3, cDNA Clone
Full Product Name
MATN3 cDNA Clone
Product Gene Name
MATN3 cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
ATGCCGCGCC CGGCCCCCGC GCGCCGCCTC CCGGGACTCC TCCTGCTGCT CTGGCCGCTG CTGCTGCTGC CCTCCGCCGC CCCCGACCCC GTGGCCCGCC CGGGCTTCCG GAGGCTGGAG ACCCGAGGTC CCGGGGGCAG CCCTGGACGC CGCCCCTCTC CTGCGGCTCC CGACGGCGCG CCCGCTTCCG GGACCAGCGA GCCTGGCCGC GCCCGCGGTG CAGGTGTTTG CAAGAGCAGA CCCTTGGACC TGGTGTTTAT CATTGATAGT TCTCGTAGCG TACGGCCCCT GGAATTCACC AAAGTGAAAA CTTTTGTCTC CCGGATAATC GACACTCTGG ACATTGGGCC AGCCGACACG CGGGTGGCAG TGGTGAACTA TGCTAGCACT GTGAAGATCG AGTTCCAACT CCAGGCCTAC ACAGATAAGC AGTCCCTGAA GCAGGCCGTG GGTCGAATCA CACCCTTGTC AACAGGCACC ATGTCAGGCC TAGCCATCCA GACAGCAATG GACGAAGCCT TCACAGTGGA GGCAGGGGCT CGAGAGCCCT CTTCTAACAT CCCTAAGGTG GCCATCATTG TTACAGATGG GAGGCCCCAG GACCAGGTGA ATGAGGTGGC GGCTCGGGCC CAAGCATCTG GTATTGAGCT CTATGCTGTG GGCGTGGACC GGGCAGACAT GGCGTCCCTC AAGATGATGG CCAGTGAGCC CCTAGAGGAG CATGTTTTCT ACGTGGAGAC CTATGGGGTC ATTGAGAAAC TTTCCTCTAG ATTCCAGGAA ACCTTCTGTG CGCTGGACCC CTGTGTGCTT GGAACACACC AGTGCCAGCA CGTCTGCATC AGTGATGGGG AAGGCAAGCA CCACTGTGAG TGTAGCCAAG GATACACCTT GAATGCCGAC AAGAAAACGT GTTCAGCTCT TGATAGGTGT GCTCTTAACA CCCACGGATG TGAGCACATC TGTGTGAATG ACAGAAGTGG CTCTTATCAT TGTGAGTGCT ATGAAGGTTA TACCTTGAAT GAAGACAGGA AAACTTGTTC AGCTCAAGAT AAATGTGCTT TGGGTACCCA TGGGTGTCAG CACATTTGTG TGAATGACAG AACAGGGTCC CATCATTGTG AATGCTATGA GGGCTACACT CTGAATGCAG ATAAAAAAAC ATGTTCAGTC CGTGACAAGT GTGCCCTAGG CTCTCATGGT TGCCAGCACA TTTGTGTGAG TGATGGGGCC GCATCCTACC ACTGTGATTG CTATCCTGGC TACACCTTAA ATGAGGACAA GAAAACATGT TCAGCCACTG AGGAAGCACG AAGACTTGTT TCCACTGAAG ATGCTTGTGG ATGTGAAGCT ACACTGGCAT TCCAGGACAA GGTCAGCTCG TATCTTCAAA GACTGAACAC TAAACTTGAT GACATTTTGG AGAAGTTGAA AATAAATGAA TATGGACAAA TACATCGTTA A
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of MATN3 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for MATN3. It may not necessarily be applicable to this product.
NCBI Accession #
BC139907
[Other Products]
UniProt Secondary Accession #
Q4ZG02; B2CPU0[Other Products]
UniProt Related Accession #
O15232[Other Products]
Molecular Weight
48,317 Da
NCBI Official Full Name
Homo sapiens matrilin 3, mRNA
NCBI Official Synonym Full Names
matrilin 3
NCBI Official Symbol
MATN3??[Similar Products]
NCBI Official Synonym Symbols
HOA; OS2; EDM5; DIPOA; OADIP
??[Similar Products]
NCBI Protein Information
matrilin-3
UniProt Protein Name
Matrilin-3
UniProt Gene Name
MATN3??[Similar Products]
UniProt Entry Name
MATN3_HUMAN
NCBI Summary for MATN3
This gene encodes a member of von Willebrand factor A domain containing protein family. This family of proteins is thought to be involved in the formation of filamentous networks in the extracellular matrices of various tissues. This protein contains two von Willebrand factor A domains; it is present in the cartilage extracellular matrix and has a role in the development and homeostasis of cartilage and bone. Mutations in this gene result in multiple epiphyseal dysplasia. [provided by RefSeq, Jul 2008]
UniProt Comments for MATN3
MATN3: Major component of the extracellular matrix of cartilage and may play a role in the formation of extracellular filamentous networks. Defects in MATN3 are the cause of multiple epiphyseal dysplasia type 5 (EDM5). EDM is a generalized skeletal dysplasia associated with significant morbidity. Joint pain, joint deformity, waddling gait, and short stature are the main clinical signs and symptoms. EDM is broadly categorized into the more severe Fairbank and the milder Ribbing types. EDM5 is relatively mild and clinically variable. It is primarily characterized by delayed and irregular ossification of the epiphyses and early-onset osteoarthritis. Defects in MATN3 are the cause of spondyloepimetaphyseal dysplasia MATN3-related (SEMD-MATN3). A bone disease characterized by disproportionate early-onset dwarfism, bowing of the lower limbs, lumbar lordosis and normal hands. Skeletal abnormalities include short, wide and stocky long bones with severe epiphyseal and metaphyseal changes, hypoplastic iliac bones and flat, ovoid vertebral bodies. Genetic variations in MATN3 are associated with susceptibility to osteoarthritis type 2 (OS2); also called osteoarthritis of distal interphalangeal joints (OADIP) or hand osteoarthritis (HOA). Osteoarthritis is a degenerative disease of the joints characterized by degradation of the hyaline articular cartilage and remodeling of the subchondral bone with sclerosis. Clinical symptoms include pain and joint stiffness often leading to significant disability and joint replacement. In the hand, osteoarthritis can develop in the distal interphalangeal and the first carpometacarpal (base of thumb) and proximal interphalangeal joints. Patients with osteoarthritis may have one, a few, or all of these sites affected.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 2p24-p23
Cellular Component: extracellular region
Molecular Function: extracellular matrix structural constituent; protein binding
Biological Process: extracellular matrix organization and biogenesis; skeletal development
Disease: Epiphyseal Dysplasia, Multiple, 5; Osteoarthritis Susceptibility 2; Spondyloepimetaphyseal Dysplasia, Matrilin-3 Related
Research Articles on MATN3
1. This report is the first to show the involvement of MATN3 in C-type natriuretic peptide/natriuretic peptide receptor-B signaling pathway during the process of transforming growth factor-beta induced chondrogenic differentiation of mesenchymal stem cells.
Precautions
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Disclaimer
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