Product Name
NR0B1, cDNA Clone
Full Product Name
NR0B1 cDNA Clone
Product Gene Name
NR0B1 cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atggcgggcg agaaccacca gtggcagggc agcatcctct acaacatgct tatgagcgcg aagcaaacgc gcgcggctcc tgaggctcca gagacgcggc tggtggatca gtgctggggc tgttcgtgcg gcgatgagcc cggggtgggc agagaggggc tgctgggcgg gcggaacgtg gcgctcctgt accgctgctg cttttgcggt aaagaccacc cacggcaggg cagcatcctc tacagcatgc tgacgagcgc aaagcaaacg tacgcggcac cgaaggcgcc cgaggcgacg ctgggtccgt gctggggctg ttcgtgcggc tctgatcccg gggtgggcag agcggggctt ccgggtgggc ggcccgtggc actcctgtac cgctgctgct tttgtggtga agaccacccg cggcagggca gcatcctcta cagcttgctc actagctcaa agcaaacgca cgtggctccg gcagcgcccg aggcacggcc agggggcgcg tggtgggacc gctcctactt cgcgcagagg ccagggggta aagaggcgct accaggcggg cgggccacgg cgcttctgta ccgctgctgc ttttgcggtg aagaccaccc gcagcagggc agcaccctct actgcgtgcc cacgagcaca aatcaagcgc aggcggctcc ggaggagcgg ccgagggccc cctggtggga cacctcctct ggtgcgctgc ggccggtggc gctcaagagt ccacaggtgg tctgcgaggc agcctcagcg ggcctgttga agacgctgcg cttcgtcaag tacttgccct gcttccaggt gctgcccctg gaccagcagc tggtgctggt gcgcaactgc tgggcgtccc tgctcatgct tgagctggcc caggaccgct tgcagttcga gactgtggaa gtctcggagc ccagcatgct gcagaagatc ctcaccacca ggcggcggga gaccgggggc aacgagccac tgcccgtgcc cacgctgcag caccatttgg caccgccggc ggaggccagg aaggtgccct ccgcctccca ggtccaagcc atcaagtgct ttctttccaa atgctggagt ctgaacatca gtaccaagga gtacgcctac ctcaagggga ccgtgctctt taacccggac gtgccgggcc tgcagtgcgt gaagtacatt cagggactcc agtggggaac tcagcaaata ctcagtgaac acaccaggat gacgcaccaa gggccccatg acagattcat cgaacttaat agtacccttt tcctgctgag attcatcaat gccaatgtca ttgctgaact gttcttcagg cccatcatcg gcacagtcag catggatgat atgatgctgg aaatgctctg tacaaagata taa
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of NR0B1 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for NR0B1. It may not necessarily be applicable to this product.
NCBI Accession #
BC011564
[Other Products]
UniProt Secondary Accession #
Q96F69[Other Products]
UniProt Related Accession #
P51843[Other Products]
Molecular Weight
43,590 Da
NCBI Official Full Name
Homo sapiens nuclear receptor subfamily 0, group B, member 1, mRNA
NCBI Official Synonym Full Names
nuclear receptor subfamily 0 group B member 1
NCBI Official Symbol
NR0B1??[Similar Products]
NCBI Official Synonym Symbols
AHC; AHX; DSS; GTD; HHG; AHCH; DAX1; DAX-1; NROB1; SRXY2
??[Similar Products]
NCBI Protein Information
nuclear receptor subfamily 0 group B member 1
UniProt Protein Name
Nuclear receptor subfamily 0 group B member 1
UniProt Synonym Protein Names
DSS-AHC critical region on the X chromosome protein 1; Nuclear receptor DAX-1
Protein Family
Nuclear receptor subfamily
UniProt Gene Name
NR0B1??[Similar Products]
UniProt Synonym Gene Names
AHC; DAX1??[Similar Products]
UniProt Entry Name
NR0B1_HUMAN
NCBI Summary for NR0B1
This gene encodes a protein that contains a DNA-binding domain. The encoded protein acts as a dominant-negative regulator of transcription which is mediated by the retinoic acid receptor. This protein also functions as an anti-testis gene by acting antagonistically to Sry. Mutations in this gene result in both X-linked congenital adrenal hypoplasia and hypogonadotropic hypogonadism. [provided by RefSeq, Jul 2008]
UniProt Comments for NR0B1
NR0B1: orphan nuclear receptor. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. Acts as a coregulatory protein that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency. Homodimerizes with STF-1, NR5A2, NR0B2 and with COPS2. Shuttles between the cytoplasm and nucleus. Homodimers exits in the cytoplasm and in the nucleus. Homodimerization involved an interaction between amino and carboxy termini involving LXXLL motifs and steroid binding domain (AF-2 motif). Heterodimerizes with STF-1 and NROB2 through its N-terminal LXXLL motifs. Defects in NR0B1 are the cause of congenital X-linked adrenal hypoplasia. Two alternatively spliced human isoforms have been described.
Protein type: Nuclear receptor
Chromosomal Location of Human Ortholog: Xp21.3
Cellular Component: cytoplasm; membrane; nucleoplasm; nucleus; polysomal ribosome
Molecular Function: DNA binding; DNA hairpin binding; ligand-dependent nuclear receptor activity; protein binding; protein domain specific binding; protein homodimerization activity; RNA binding; sequence-specific DNA binding; steroid hormone receptor binding; transcription corepressor activity; transcription factor binding
Biological Process: adrenal gland development; gonad development; male gonad development; negative regulation of steroid hormone receptor signaling pathway; negative regulation of transcription factor activity; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; protein localization; steroid biosynthetic process; transcription initiation from RNA polymerase II promoter
Disease: 46,xy Sex Reversal 2; Adrenal Hypoplasia, Congenital
Research Articles on NR0B1
1. DAX1 and SF1 expression positively correlated in pediatric adrenocortical tumors, suggesting that these transcription factors might cooperate in adrenocortical tumorigenesis.
Precautions
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Disclaimer
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