Product Name
SGLT-2, Polyclonal Antibody
Full Product Name
SGLT-2 Polyclonal Antibody
Product Gene Name
anti-SGLT-2 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P31639
Other Notes
Small volumes of anti-SGLT-2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for SGLT-2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_003032.1
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NCBI GenBank Nucleotide #
NM_003041.3
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UniProt Primary Accession #
P31639
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UniProt Secondary Accession #
A2RRD2[Other Products]
UniProt Related Accession #
P31639[Other Products]
Molecular Weight
49,357 Da
NCBI Official Full Name
sodium/glucose cotransporter 2
NCBI Official Synonym Full Names
solute carrier family 5 member 2
NCBI Official Symbol
SLC5A2??[Similar Products]
NCBI Official Synonym Symbols
SGLT2
??[Similar Products]
NCBI Protein Information
sodium/glucose cotransporter 2
UniProt Protein Name
Sodium/glucose cotransporter 2
UniProt Synonym Protein Names
Low affinity sodium-glucose cotransporter; Solute carrier family 5 member 2
UniProt Gene Name
SLC5A2??[Similar Products]
UniProt Synonym Gene Names
; Na(+)/glucose cotransporter 2??[Similar Products]
NCBI Summary for SGLT-2
This gene encodes a member of the sodium glucose cotransporter family which are sodium-dependent glucose transport proteins. The encoded protein is the major cotransporter involved in glucose reabsorption in the kidney. Mutations in this gene are associated with renal glucosuria. Two transcript variants, one protein-coding and one not, have been found for this gene. [provided by RefSeq, Feb 2015]
UniProt Comments for SGLT-2
Sodium-dependent glucose transporter. Has a Na+ to glucose coupling ratio of 1:1.
Research Articles on SGLT-2
1. Data suggest expression of SGLT1 is markedly increased in kidney of patients with type 2 diabetes as compared to control subjects; SGLT1 mRNA is highly and significantly correlated with fasting and postprandial plasma glucose and HbA1c. In contrast, data suggest SGLT2 and GLUT2 mRNA in kidney are down-regulated in type 2 diabetes, but not to statistically significant level. (GLUT2 = glucose transporter type 2)
Precautions
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Disclaimer
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