Full Product Name
Nr0b1 Antibody - C-terminal region
Product Gene Name
anti-NR0B1 antibody
[Similar Products]
Product Synonym Gene Name
AHX; Ahc; Ahch; DAX-1; Dax1[Similar Products]
Antibody/Peptide Pairs
Nr0b1 peptide (MBS3226238) is used for blocking the activity of Nr0b1 antibody (MBS3201214)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
Synthetic peptide located within the following region: YIEGLQWRTQ QILTEHIRMM QREYQIRSAE LNSALFLLRF INSDVVTELF
3D Structure
ModBase 3D Structure for Q61066
Species Reactivity
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
Purity/Purification
Affinity Purified
Form/Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Homology
Cow: 92%; Dog: 75%; Guinea Pig: 92%; Horse: 83%; Human: 100%; Mouse: 92%; Rabbit: 92%; Rat: 92%
Immunogen
The immunogen is a synthetic peptide directed towards the C-terminal region of Mouse Nr0b1
Preparation and Storage
For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Other Notes
Small volumes of anti-NR0B1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-NR0B1 antibody
This is a rabbit polyclonal antibody against Nr0b1. It was validated on Western Blot
Target Description: Nr0b1 is an orphan nuclear receptor and a component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. Nr0b1 acts as a coregulatory protein that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. Nr0b1 may also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency.
Product Categories/Family for anti-NR0B1 antibody
Polyclonal; Transcription Factor; Signaling Intermediate; Developmental Biology;
Applications Tested/Suitable for anti-NR0B1 antibody
Western Blot (WB)
Western Blot (WB) of anti-NR0B1 antibody
WB Suggested Anti-Nr0b1 Antibody
Titration: 1.0 ug/ml
Positive Control: Mouse Testis
NCBI/Uniprot data below describe general gene information for NR0B1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_031456
[Other Products]
NCBI GenBank Nucleotide #
NM_007430
[Other Products]
UniProt Primary Accession #
Q61066
[Other Products]
UniProt Related Accession #
Q61066[Other Products]
NCBI Official Full Name
nuclear receptor subfamily 0 group B member 1
NCBI Official Synonym Full Names
nuclear receptor subfamily 0, group B, member 1
NCBI Official Symbol
Nr0b1??[Similar Products]
NCBI Official Synonym Symbols
AHX; Ahc; Ahch; Dax1; DAX-1
??[Similar Products]
NCBI Protein Information
nuclear receptor subfamily 0 group B member 1
UniProt Protein Name
Nuclear receptor subfamily 0 group B member 1
UniProt Synonym Protein Names
Nuclear receptor DAX-1
Protein Family
Nuclear receptor subfamily
UniProt Gene Name
Nr0b1??[Similar Products]
UniProt Synonym Gene Names
Ahch; Dax1??[Similar Products]
UniProt Entry Name
NR0B1_MOUSE
NCBI Summary for NR0B1
This gene encodes an orphan nuclear receptor protein that plays a key role in differentiation of the gonads. This protein regulates steroidogenic factor 1 (Sf-1) in a dose-dependent manner, sometimes functioning as a repressor of SF-1 target genes, and sometimes functioning as a co-activator. Overexpression of this gene can cause feminization of the XY male gonads. This gene is also involved in the maintenance of embryonic stem cell pluripotancy. Mutations in the related gene in human cause congenital adrenal hypoplasia and hypogonadotropic hypogonadism. [provided by RefSeq, May 2015]
Research Articles on NR0B1
1. CpG methylation within the NR0B1 promoter is not involved in the in vivo regulation of NR0B1 expression, whereas the hyperacetylation of histone H4 and the unmethylation of histones H3K9 and H3K27, and their binding to the NR0B1 promoter results in decondensed euchromatin for NR0B1 activation.
Precautions
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Disclaimer
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