Full Product Name
SGLT2 Rabbit Polyclonal
Product Gene Name
anti-SGLT2 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Purity/Purification
>=95% as determined by SDS-PAGE
Immunogen Affinity Purified
Immunogen
Solute carrier family 5 (sodium/glucose cotransporter), member 2
Preparation and Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-SGLT2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-SGLT2 antibody
ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB)
NCBI/Uniprot data below describe general gene information for SGLT2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_003032.1
[Other Products]
NCBI GenBank Nucleotide #
NM_003041.3
[Other Products]
UniProt Secondary Accession #
A2RRD2[Other Products]
UniProt Related Accession #
P31639[Other Products]
Molecular Weight
49,357 Da
NCBI Official Full Name
sodium/glucose cotransporter 2
NCBI Official Synonym Full Names
solute carrier family 5 member 2
NCBI Official Symbol
SLC5A2??[Similar Products]
NCBI Official Synonym Symbols
SGLT2
??[Similar Products]
NCBI Protein Information
sodium/glucose cotransporter 2
UniProt Protein Name
Sodium/glucose cotransporter 2
UniProt Synonym Protein Names
Low affinity sodium-glucose cotransporter; Solute carrier family 5 member 2
UniProt Gene Name
SLC5A2??[Similar Products]
UniProt Synonym Gene Names
SGLT2; Na(+)/glucose cotransporter 2??[Similar Products]
UniProt Entry Name
SC5A2_HUMAN
NCBI Summary for SGLT2
This gene encodes a member of the sodium glucose cotransporter family which are sodium-dependent glucose transport proteins. The encoded protein is the major cotransporter involved in glucose reabsorption in the kidney. Mutations in this gene are associated with renal glucosuria. Two transcript variants, one protein-coding and one not, have been found for this gene. [provided by RefSeq, Feb 2015]
UniProt Comments for SGLT2
SLC5A2: Sodium-dependent glucose transporter. Has a Na(+) to glucose coupling ratio of 1:1. Defects in SLC5A2 are the cause of renal glucosuria (GLYS1). GLYS1 is an autosomal recessive disorder characterized by a normal fasting serum glucose concentration and persistent isolated glucosuria, with a normal glucose tolerance test. Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
Protein type: Membrane protein, integral; Transporter; Membrane protein, multi-pass; Transporter, SLC family
Chromosomal Location of Human Ortholog: 16p11.2
Cellular Component: brush border membrane; integral to membrane; integral to plasma membrane; plasma membrane
Molecular Function: glucose:sodium symporter activity; low-affinity glucose:sodium symporter activity
Biological Process: carbohydrate metabolic process; sodium ion transport; transport
Disease: Renal Glucosuria
Research Articles on SGLT2
1. Data show that thiosugars bind to sodium-glucose co-transporters vSGLT and hSGLT2 stronger and dissociate more slowly than sugars.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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