Product Name
SGLT2, Polyclonal Antibody
Popular Item
Full Product Name
SGLT2 Antibody
Product Synonym Names
Low affinity sodium glucose cotransporter; Na(+) glucose cotransporter 2; SGLT 2; SLC5A2; Sodium glucose cotransporter 2; Solute carrier family 5 (sodium glucose cotransporter) member 2 antibodySolute carrier family 5 member 2 antibody
Product Gene Name
anti-SGLT2 antibody
[Similar Products]
Matching Pairs
Antibody: SGLT2 (MBS544866)
Positive Control: SGLT2 (MBS543251)
Antibody/Peptide Pairs
SGLT2 peptide (MBS544463) is used for blocking the activity of SGLT2 antibody (MBS544866)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P31639
Species Reactivity
Human, Monkey, Mouse
Form/Format
Affinity Purified Immunoglobulins
Concentration
0.68 ug/ul in antibody stabilization buffer (lot specific)
Immunogen
Synthetic peptide taken within amino acid region 580-630 on human SGLT2 protein.
Preparation and Storage
Store at -20?°C for long term storage
Other Notes
Small volumes of anti-SGLT2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-SGLT2 antibody
Affinity Purified Sodium/glucose cotransporter 2 Antibody
Sodium-dependent glucose transporter. Has a Na+ to glucose coupling ratio of 1:1.
Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na+/glucose cotransporter arranged in series along kidney proximal tubules.
Product Categories/Family for anti-SGLT2 antibody
Primary Antibodies; Channels & Transporters; SGLT2 Antibody
Applications Tested/Suitable for anti-SGLT2 antibody
Confocal Microscopy (CM), ELISA (EIA), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB)
Application Notes for anti-SGLT2 antibody
Confocal Microscopy||1:50
Dot Blot: 1:10,000
ELISA: 1:10,000
Immunocytochemistry: 1:50
Immunofluorescence: 1:50
Immunohistochemistry: 1:50
Immunoprecipitation: 1:150
Western Blot: 1:500
Western Blot (WB) of anti-SGLT2 antibody
Immunohistochemistry (IHC) of anti-SGLT2 antibody
NCBI/Uniprot data below describe general gene information for SGLT2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_003032
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NCBI GenBank Nucleotide #
NM_003041.3
[Other Products]
UniProt Primary Accession #
P31639
[Other Products]
UniProt Secondary Accession #
A2RRD2[Other Products]
UniProt Related Accession #
P31639[Other Products]
NCBI Official Full Name
sodium/glucose cotransporter 2
NCBI Official Synonym Full Names
solute carrier family 5 member 2
NCBI Official Symbol
SLC5A2??[Similar Products]
NCBI Official Synonym Symbols
SGLT2
??[Similar Products]
NCBI Protein Information
sodium/glucose cotransporter 2
UniProt Protein Name
Sodium/glucose cotransporter 2
UniProt Synonym Protein Names
Low affinity sodium-glucose cotransporter; Solute carrier family 5 member 2
UniProt Gene Name
SLC5A2??[Similar Products]
UniProt Synonym Gene Names
SGLT2; Na(+)/glucose cotransporter 2??[Similar Products]
UniProt Entry Name
SC5A2_HUMAN
NCBI Summary for SGLT2
This gene encodes a member of the sodium glucose cotransporter family which are sodium-dependent glucose transport proteins. The encoded protein is the major cotransporter involved in glucose reabsorption in the kidney. Mutations in this gene are associated with renal glucosuria. Two transcript variants, one protein-coding and one not, have been found for this gene. [provided by RefSeq, Feb 2015]
UniProt Comments for SGLT2
SLC5A2: Sodium-dependent glucose transporter. Has a Na(+) to glucose coupling ratio of 1:1. Defects in SLC5A2 are the cause of renal glucosuria (GLYS1). GLYS1 is an autosomal recessive disorder characterized by a normal fasting serum glucose concentration and persistent isolated glucosuria, with a normal glucose tolerance test. Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
Protein type: Membrane protein, multi-pass; Membrane protein, integral; Transporter, SLC family; Transporter
Chromosomal Location of Human Ortholog: 16p11.2
Cellular Component: brush border membrane; integral to membrane; integral to plasma membrane; plasma membrane
Molecular Function: glucose:sodium symporter activity; low-affinity glucose:sodium symporter activity
Biological Process: carbohydrate metabolic process; sodium ion transport; transport
Disease: Renal Glucosuria
Research Articles on SGLT2
1. Data show that thiosugars bind to sodium-glucose co-transporters vSGLT and hSGLT2 stronger and dissociate more slowly than sugars.
Precautions
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Disclaimer
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