Product Name
SGLT2 (SLC5A2), Polyclonal Antibody
Popular Item
Full Product Name
Anti-SGLT2 Antibody
Product Synonym Names
SGLT2; Sodium/glucose cotransporter 2; Na(+)/glucose cotransporter 2; Low affinity sodium-glucose cotransporter; Solute carrier family 5 member 2
Product Gene Name
anti-SLC5A2 antibody
[Similar Products]
Antibody/Peptide Pairs
SGLT2 peptide (MBS823010) is used for blocking the activity of SGLT2 antibody (MBS821113)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P31639
Species Reactivity
Human, Mouse, Rat
Specificity
Recognizes endogenous levels of SGLT2 protein.
Purity/Purification
The antibody was purified by immunogen affinity chromatography.
Form/Format
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Entrez Gene
6524 (Human); 246787 (Mouse); 64522 (Rat)
SwissProt
P31639 (Human); Q923I7 (Mouse); P53792 (Rat)
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human SGLT2. The exact sequence is proprietary.
Preparation and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C for one year. Avoid freeze/thaw cycles.
Other Notes
Small volumes of anti-SLC5A2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-SLC5A2 antibody
Rabbit polyclonal antibody to SGLT2
Applications Tested/Suitable for anti-SLC5A2 antibody
Western Blot (WB)
Application Notes for anti-SLC5A2 antibody
WB (1/500 - 1/1000)
Western Blot (WB) of anti-SLC5A2 antibody
Western blot analysis of SGLT2 expression in HeLa (A), SP2/0 (B), H9C2 (C) whole cell lysates.
NCBI/Uniprot data below describe general gene information for SLC5A2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_003032.1
[Other Products]
NCBI GenBank Nucleotide #
NM_003041.3
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UniProt Primary Accession #
P31639
[Other Products]
UniProt Secondary Accession #
A2RRD2[Other Products]
UniProt Related Accession #
P31639[Other Products]
NCBI Official Full Name
sodium/glucose cotransporter 2
NCBI Official Synonym Full Names
solute carrier family 5 (sodium/glucose cotransporter), member 2
NCBI Official Symbol
SLC5A2??[Similar Products]
NCBI Official Synonym Symbols
SGLT2
??[Similar Products]
NCBI Protein Information
sodium/glucose cotransporter 2; Na(+)/glucose cotransporter 2; solute carrier family 5 member 2; low affinity sodium-glucose cotransporter; solute carrier family 5 (sodium/glucose transporter), member 2
UniProt Protein Name
Sodium/glucose cotransporter 2
UniProt Synonym Protein Names
Low affinity sodium-glucose cotransporter; Solute carrier family 5 member 2
Protein Family
Sodium/glucose cotransporter
UniProt Gene Name
SLC5A2??[Similar Products]
UniProt Synonym Gene Names
SGLT2; Na(+)/glucose cotransporter 2??[Similar Products]
UniProt Entry Name
SC5A2_HUMAN
NCBI Summary for SLC5A2
This gene encodes a member of the sodium glucose cotransporter family which are sodium-dependent glucose transport proteins. The encoded protein is the major cotransporter involved in glucose reabsorption in the kidney. Mutations in this gene are associated with renal glucosuria. [provided by RefSeq, Sep 2009]
UniProt Comments for SLC5A2
SLC5A2: Sodium-dependent glucose transporter. Has a Na(+) to glucose coupling ratio of 1:1. Defects in SLC5A2 are the cause of renal glucosuria (GLYS1). GLYS1 is an autosomal recessive disorder characterized by a normal fasting serum glucose concentration and persistent isolated glucosuria, with a normal glucose tolerance test. Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
Protein type: Transporter, SLC family; Transporter; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 16p11.2
Cellular Component: plasma membrane; integral to membrane
Molecular Function: low-affinity glucose:sodium symporter activity
Biological Process: transport; carbohydrate metabolic process; sodium ion transport; glucose transport; transmembrane transport
Disease: Renal Glucosuria
Research Articles on SLC5A2
1. A single dose of canagliflozin, a sodium glucose co-transporter 2 inhibitor, 300 mg reduced both fasting and postprandial PG.
Precautions
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Disclaimer
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