Product Name
C/EBP-epsilon, Polyclonal Antibody
Full Product Name
C/EBP-epsilon (Phospho-ser181) Antibody
Product Synonym Names
C/EBP epsilon; CCAAT/enhancer binding protein (C/EBP) epsilon; CCAAT/enhancer binding protein epsilon; CCAAT/enhancer-binding protein epsilon; CEBPE; CEBPE_HUMAN; CRP 1; CRP1;
Product Gene Name
anti-C/EBP-epsilon antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q15744
Specificity
Phospho-C/EBP-ε (Phospho-ser181) Antibody detects endogenous levels of C/EBP-ε only when phosphorylated at ser181
Purity/Purification
The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
Form/Format
In phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1.0mg/mL (lot specific)
Immunogen
A synthesized peptide derived from human C/EBP-epsilon around the phosphorylation site of ser181
Preparation and Storage
Store at -20 degree C.
Other Notes
Small volumes of anti-C/EBP-epsilon antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-C/EBP-epsilon antibody
Phospho-specific Ab
Applications Tested/Suitable for anti-C/EBP-epsilon antibody
Western Blot (WB)
Application Notes for anti-C/EBP-epsilon antibody
WB: 1:500-1:2000
Western Blot (WB) of anti-C/EBP-epsilon antibody
Western blot analysis of Phospho-C/EBP (ser181) in lysates of HuvEc, using Phospho-C/EBP (ser181) Antibody(13243).
NCBI/Uniprot data below describe general gene information for C/EBP-epsilon. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001796.2
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NCBI GenBank Nucleotide #
NM_001805.3
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UniProt Primary Accession #
Q15744
[Other Products]
UniProt Secondary Accession #
Q15745; Q8IYI2; Q99803[Other Products]
UniProt Related Accession #
Q15744[Other Products]
NCBI Official Full Name
CCAAT/enhancer-binding protein epsilon
NCBI Official Synonym Full Names
CCAAT/enhancer binding protein epsilon
NCBI Official Symbol
CEBPE??[Similar Products]
NCBI Official Synonym Symbols
CRP1; C/EBP-epsilon
??[Similar Products]
NCBI Protein Information
CCAAT/enhancer-binding protein epsilon
UniProt Protein Name
CCAAT/enhancer-binding protein epsilon
UniProt Gene Name
CEBPE??[Similar Products]
UniProt Synonym Gene Names
C/EBP epsilon??[Similar Products]
NCBI Summary for C/EBP-epsilon
The protein encoded by this gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related protein CEBP-delta. The encoded protein may be essential for terminal differentiation and functional maturation of committed granulocyte progenitor cells. Mutations in this gene have been associated with Specific Granule Deficiency, a rare congenital disorder. Multiple variants of this gene have been described, but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008]
UniProt Comments for C/EBP-epsilon
Transcriptional activator (PubMed:26019275). C/EBP are DNA-binding proteins that recognize two different motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers. Required for the promyelocyte-myelocyte transition in myeloid differentiation (PubMed:10359588).
Research Articles on C/EBP-epsilon
1. G, CDKN2A rs3731246 G>C, and CDKN2A rs3731246 C allele were signi fi cantly associated with Acute Lymphoblastic Leukemia in Yemenis of Arab-Asian descent. Borderline association found in IKZF1 rs4132601 T>G variant. No associations found with IKZF1 rs11978267 or rs7789635, DDC rs3779084; rs880028; rs7809758, CDKN2A rs3731217, CEBPE rs2239633; rs12434881">IKZF1 rs10235796 C allele, IKZF1 rs6964969A>G, CDKN2A rs3731246 G>C, and CDKN2A rs3731246 C allele were signi fi cantly associated with Acute Lymphoblastic Leukemia in Yemenis of Arab-Asian descent. Borderline association found in IKZF1 rs4132601 T>G variant. No associations found with IKZF1 rs11978267 or rs7789635, DDC rs3779084; rs880028; rs7809758, CDKN2A rs3731217, CEBPE rs2239633; rs12434881
Precautions
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Disclaimer
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