Product Name
Slc5a2, Polyclonal Antibody
Full Product Name
Slc5a2 antibody - middle region
Product Gene Name
anti-SLC5A2 antibody
[Similar Products]
Product Synonym Gene Name
Sglt2[Similar Products]
Antibody/Peptide Pairs
Slc5a2 peptide (MBS3232019) is used for blocking the activity of Slc5a2 antibody (MBS3207053)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
Synthetic peptide located within the following region: SSTCYQPRPD SYHLLRDPVT GDLPWPALLL GLTIVSGWYW CSDQVIVQRC
3D Structure
ModBase 3D Structure for Q923I7
Species Reactivity
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
Purity/Purification
Affinity Purified
Form/Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Homology
Cow: 93%; Dog: 93%; Guinea Pig: 93%; Horse: 93%; Human: 100%; Mouse: 93%; Rabbit: 93%; Rat: 93%
Preparation and Storage
For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Other Notes
Small volumes of anti-SLC5A2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-SLC5A2 antibody
This is a rabbit polyclonal antibody against Slc5a2. It was validated on Western Blot
Target Description: Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na+/glucose cotransporter arranged in series along kidney proximal tubules.
Product Categories/Family for anti-SLC5A2 antibody
Polyclonal; Transcription Factor; Cell Cycle Proteins; Cell Biology; E3 & Ubiquitin; DNA/RNA/Protein Interactions; Meiosis/Mitosis/Cell Cycle;
Applications Tested/Suitable for anti-SLC5A2 antibody
Western Blot (WB)
Western Blot (WB) of anti-SLC5A2 antibody
WB Suggested Anti-Slc5a2 Antibody
Titration: 1.0 ug/ml
Positive Control: Mouse Thymus
NCBI/Uniprot data below describe general gene information for SLC5A2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_573517
[Other Products]
NCBI GenBank Nucleotide #
NM_133254
[Other Products]
UniProt Primary Accession #
Q923I7
[Other Products]
UniProt Related Accession #
Q923I7[Other Products]
NCBI Official Full Name
sodium/glucose cotransporter 2
NCBI Official Synonym Full Names
solute carrier family 5 (sodium/glucose cotransporter), member 2
NCBI Official Symbol
Slc5a2??[Similar Products]
NCBI Official Synonym Symbols
Sglt2
??[Similar Products]
NCBI Protein Information
sodium/glucose cotransporter 2
UniProt Protein Name
Sodium/glucose cotransporter 2
UniProt Synonym Protein Names
Low affinity sodium-glucose cotransporter; Solute carrier family 5 member 2
Protein Family
Sodium/glucose cotransporter
UniProt Gene Name
Slc5a2??[Similar Products]
UniProt Synonym Gene Names
Sglt2; Na(+)/glucose cotransporter 2??[Similar Products]
UniProt Entry Name
SC5A2_MOUSE
UniProt Comments for SLC5A2
SLC5A2: Sodium-dependent glucose transporter. Has a Na(+) to glucose coupling ratio of 1:1. Defects in SLC5A2 are the cause of renal glucosuria (GLYS1). GLYS1 is an autosomal recessive disorder characterized by a normal fasting serum glucose concentration and persistent isolated glucosuria, with a normal glucose tolerance test. Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
Protein type: Transporter, SLC family; Membrane protein, multi-pass; Transporter; Membrane protein, integral
Cellular Component: brush border membrane; integral to membrane; membrane
Molecular Function: glucose:sodium symporter activity; protein binding; symporter activity; transporter activity
Biological Process: carbohydrate transport; glucose transport; ion transport; sodium ion transport; transmembrane transport; transport
Research Articles on SLC5A2
1. An inhibitor of the renal sodium/glucose cotransporter 2 (SGLT2), dapagliflozin, successfully prevented the development of cardiomyopathy in SKO mice. This is particularly relevant, given that SGLT2i treatment reduces cardiovascular event in T2DM patients. [review]
Precautions
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Disclaimer
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