Product Name
SLC26A2, cDNA Clone
Full Product Name
SLC26A2 cDNA Clone
Product Gene Name
SLC26A2 cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atgtcttcag aaagtaaaga gcaacataac gtttcaccca gagactcagc tgaaggaaat gacagttatc catctgggat ccatctggaa cttcaaaggg aatcaagtac tgacttcaag caatttgaga ccaatgatca atgcagacct tatcatagga tccttattga gcgtcaagag aaatcagata caaacttcaa ggagtttgtt attaaaaagc tgcagaagaa ttgccagtgc agtccagcca aagccaaaaa tatgatttta ggtttccttc ctgttttgca gtggctccca aaatacgacc taaagaaaaa cattttaggg gatgtgatgt caggcttgat tgtgggcata ttattggtgc cccagtccat tgcttattcc ctgctggctg gccaagaacc tgtctatggt ctgtacacat ctttttttgc cagcatcatt tattttctct tgggtacctc ccgtcacatc tctgtgggca tttttggagt actgtgcctt atgattggtg agacagttga ccgagaacta cagaaagctg gctatgacaa tgcccatagt gctccttcct taggaatggt ttcaaatggg agcacattat taaatcatac atcagacagg atatgtgaca aaagttgcta tgcaattatg gttggcagca ctgtaacctt tatagctgga gtttatcagg tagcgatggg cttctttcaa gtgggttttg tttctgtcta cctctcagat gccttgctga gtggatttgt cactggtgcc tccttcacta ttcttacatc tcaggccaag tatcttcttg ggctcaacct tcctcggact aatggtgtgg gctcactcat cactacctgg atacatgtct tcagaaacat ccataagacc aatctctgtg atcttatcac cagccttttg tgccttttgg ttcttttgcc aaccaaagaa ctcaatgaac acttcaaatc caagcttaag gcaccgattc ctattgaact tgttgttgtt gtagcagcca cattagcctc tcattttgga aaactacatg aaaattataa ttctagtatt gctggacata ttcccactgg gtttatgcca cccaaagtac cagaatggaa cctaattcct agtgtggctg tagatgcaat agctatttcc atcattggtt ttgctatcac tgtatcactt tctgagatgt ttgccaagaa acatggttac acagtcaaag caaaccagga aatgtatgcc attggctttt gtaatatcat cccttccttc ttccactgtt ttactactag tgcagctctt gcaaagacat tggttaaaga atcaacaggc tgccatactc agctttctgg tgtggtaaca gccctggttc ttttgttggt cctcctagta atagctcctt tgttctattc ccttcaaaaa agtgtccttg gtgtgatcac aattgtaaat ctacggggag cccttcgtaa atttagggat cttcccaaaa tgtggagtat tagtagaatg gatacagtta tctggtttgt tactatgctg tcctctgcac tgctaagtac tgaaataggc ctacttgttg gggtttgttt ttctatattt tgtgtcatcc tccgcactca gaagccaaag agttcactgc ttggcttggt ggaagagtct gaggtctttg aatctgtgtc tgcttacaag aaccttcaga ctaagccagg catcaagatt ttccgctttg tagcccctct ctactacata aacaaagaat gctttaaatc tgctttatac aaacaaactg tcaacccaat cttaataaag gtggcttgga agaaggcagc aaagagaaag atcaaagaaa aagtagtgac tcttggtgga atccaggatg aaatgtcagt gcaactttcc catgatccct tggagctgca tactatagtg attgactgca gtgcaattca atttttagat acagcaggga tccacacact gaaagaagtt cgcagagatt atgaagccat tggaatccag gttctgctgg ctcagtgcaa tcccactgtg agggattccc taaccaacgg agaatattgc aaaaaggaag aagaaaacct tctcttctat agtgtgtatg aagcgatggc ttttgcagaa gtatctaaaa atcagaaagg agtatgtgtt cccaatggtc tgagtcttag tagtgattaa
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of SLC26A2 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for SLC26A2. It may not necessarily be applicable to this product.
NCBI Accession #
BC059390
[Other Products]
UniProt Secondary Accession #
Q6N051; A8K2U3; B2R6J1[Other Products]
UniProt Related Accession #
P50443[Other Products]
Molecular Weight
81,662 Da
NCBI Official Full Name
Homo sapiens solute carrier family 26 (sulfate transporter), member 2, mRNA
NCBI Official Synonym Full Names
solute carrier family 26 member 2
NCBI Official Symbol
SLC26A2??[Similar Products]
NCBI Official Synonym Symbols
DTD; EDM4; DTDST; MST153; D5S1708; MSTP157
??[Similar Products]
NCBI Protein Information
sulfate transporter
UniProt Protein Name
Sulfate transporter
UniProt Synonym Protein Names
Diastrophic dysplasia protein; Solute carrier family 26 member 2
Protein Family
Sulfate transporter
UniProt Gene Name
SLC26A2??[Similar Products]
UniProt Synonym Gene Names
DTD; DTDST??[Similar Products]
UniProt Entry Name
S26A2_HUMAN
NCBI Summary for SLC26A2
The diastrophic dysplasia sulfate transporter is a transmembrane glycoprotein implicated in the pathogenesis of several human chondrodysplasias. It apparently is critical in cartilage for sulfation of proteoglycans and matrix organization. [provided by RefSeq, Jul 2008]
UniProt Comments for SLC26A2
SLC26A2: Sulfate transporter. May play a role in endochondral bone formation. Defects in SLC26A2 are the cause of diastrophic dysplasia (DTD). DTD is an autosomal recessive disease characterized by osteochondrodysplasia with clinical features including dwarfism, spinal deformation, and specific joint abnormalities. Defects in SLC26A2 are the cause of achondrogenesis type 1B (ACG1B). ACG1B is a recessively inherited chondrodysplasia characterized by extremely poor skeletal development and perinatal death. Defects in SLC26A2 are the cause of atelosteogenesis type 2 (AO2); also known as neonatal osseous dysplasia 1. AO2 is characterized by severely shortened limbs, small chest, scoliosis, club foot of the equinovarus type (talipes equinovarus), abducted thumbs and great toes, and cleft palate. Patients die of respiratory insufficiency shortly after birth because of the collapse of the airways and pulmonary hypoplasia due to the small rib cage. Defects in SLC26A2 are the cause of multiple epiphyseal dysplasia type 4 (EDM4). EDM is a generalized skeletal dysplasia associated with significant morbidity. Joint pain, joint deformity, waddling gait, and short stature are the main clinical signs and symptoms. EDM is broadly categorized into the more severe Fairbank and the milder Ribbing types. EDM4 is a recessively inherited form, characterized by early childhood-onset hip dysplasia and recurrent patella dislocation. Short stature in EDM4 patients is not frequent. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
Protein type: Membrane protein, multi-pass; Membrane protein, integral; Transporter, SLC family; Transporter
Chromosomal Location of Human Ortholog: 5q31-q34
Cellular Component: integral to plasma membrane; membrane; plasma membrane
Molecular Function: anion:anion antiporter activity; bicarbonate transmembrane transporter activity; chloride channel activity; oxalate transmembrane transporter activity; sulfate transmembrane transporter activity
Biological Process: 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process; bicarbonate transport; ion transport; regulation of intracellular pH; regulation of membrane potential; sulfate transport
Disease: Achondrogenesis, Type Ib; Atelosteogenesis, Type Ii; Diastrophic Dysplasia; Epiphyseal Dysplasia, Multiple, 4
Research Articles on SLC26A2
1. slc26a2 is to be a critical otic gene whose dysfunction may induce hearing impairment
Precautions
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Disclaimer
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