Product Name
Cone-rod homeobox protein (CRX), Recombinant Protein
Full Product Name
Recombinant Bovine Cone-rod homeobox protein (CRX)
Product Gene Name
CRX recombinant protein
[Similar Products]
Product Synonym Gene Name
CRX[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
1-299aa, full length protein
Sequence
MMAYMNPGPH YSVNALALSG PSVDLMHPAV SYPSAPRKQR RERTTFTRSQ LEELEALFAK TQYPDVYARE EVALKINLPE SRVQVWFKNR RAKCRQQRQQ QKQQQQPPGA QAKARPAKRK AGTSPRSSTD VCPDPLGISD SYSPPLPGPS GSPTTAVATV SIWSPASESP LPEAQRAGLV ASGPSLTSAP YAMTYAPASA FCSSPSAYGS PSSYFSGLDP YLSPMVPPLG GPALSPLSGP SVGPSLTQSP TSLSGQSYGT YSPVDSLEFK DPTGTWKFTY NPMDPLDYKD QSAWKFQIL
3D Structure
ModBase 3D Structure for Q9XSK0
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of CRX recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
CRX recombinant protein
This protein is a photoreceptor-specific transcription factor which plays a role in the differentiation of photoreceptor cells. This homeodomain protein is necessary for the maintenance of normal cone and rod function. Mutations in this gene are associated with photoreceptor degeneration, Leber congenital amaurosis type III and the autosomal dominant cone-rod dystrophy 2. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some variants has not been determined.
NCBI/Uniprot data below describe general gene information for CRX. It may not necessarily be applicable to this product.
NCBI Accession #
NP_776329.1
[Other Products]
NCBI GenBank Nucleotide #
NM_173904.2
[Other Products]
UniProt Primary Accession #
Q9XSK0
[Other Products]
UniProt Related Accession #
Q9XSK0[Other Products]
Molecular Weight
32,253 Da
NCBI Official Full Name
cone-rod homeobox protein
NCBI Official Symbol
CRX??[Similar Products]
NCBI Protein Information
cone-rod homeobox protein
UniProt Protein Name
Cone-rod homeobox protein
Protein Family
Cone-rod homeobox protein
UniProt Gene Name
CRX??[Similar Products]
UniProt Comments for CRX
Transcription factor that binds and transactivates the sequence 5'-TAATC[CA]-3' which is found upstream of several photoreceptor-specific genes, including the opsin genes. Acts synergistically with other transcription factors, such as NRL, RORB and RAX, to regulate photoreceptor cell-specific gene transcription. Essential for the maintenance of mammalian photoreceptors ().
Research Articles on CRX
1. OTR1, OTX2 and CRX act as positive modulators of the BEST1 promoter in the retinal pigment epithelium.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
