Product Name
FGF-23, Polyclonal Antibody
Full Product Name
FGF-23 Polyclonal Antibody
Product Gene Name
anti-FGF-23 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9GZV9
Other Notes
Small volumes of anti-FGF-23 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for FGF-23. It may not necessarily be applicable to this product.
NCBI Accession #
NP_065689.1
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NCBI GenBank Nucleotide #
NM_020638.2
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UniProt Primary Accession #
Q9GZV9
[Other Products]
UniProt Secondary Accession #
Q4V758[Other Products]
UniProt Related Accession #
Q9GZV9[Other Products]
Molecular Weight
27,954 Da
NCBI Official Full Name
fibroblast growth factor 23
NCBI Official Synonym Full Names
fibroblast growth factor 23
NCBI Official Symbol
FGF23??[Similar Products]
NCBI Official Synonym Symbols
ADHR; FGFN; HYPF; HPDR2; PHPTC
??[Similar Products]
NCBI Protein Information
fibroblast growth factor 23
UniProt Protein Name
Fibroblast growth factor 23
UniProt Synonym Protein Names
Phosphatonin; Tumor-derived hypophosphatemia-inducing factor
UniProt Gene Name
FGF23??[Similar Products]
UniProt Synonym Gene Names
HYPF; FGF-23??[Similar Products]
NCBI Summary for FGF-23
This gene encodes a member of the fibroblast growth factor family of proteins, which possess broad mitogenic and cell survival activities and are involved in a variety of
biological processes. The product of this gene regulates phosphate homeostasis and transport in the kidney. The full-length, functional protein may be deactivated via cleavage into N-terminal and C-terminal chains. Mutation of this cleavage site causes autosomal dominant hypophosphatemic rickets (ADHR). Mutations in this gene are also associated with hyperphosphatemic familial tumoral calcinosis (HFTC). [provided by RefSeq, Feb 2013]
UniProt Comments for FGF-23
Regulator of phosphate homeostasis. Inhibits renal tubular phosphate transport by reducing SLC34A1 levels. Upregulates EGR1 expression in the presence of KL (). Acts directly on the parathyroid to decrease PTH secretion (). Regulator of vitamin-D metabolism. Negatively regulates osteoblast differentiation and matrix mineralization.
Research Articles on FGF-23
1. This study indicates a possible mechanism by which excessive levels of FGF23 are involved in endothelial thrombomodulin disruption, which has been implicated as a potential cardiovascular risk factor in patients with chronic kidney disease, especially in hemodialysis patients
Precautions
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Disclaimer
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