Product Name
SLC5A2 / SGLT2, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal to Human SLC5A2 / SGLT2
Product Synonym Names
Anti-SLC5A2 / SGLT2 Antibody (C-Terminus) IHC-plus; SLC5A2; Na(+)/glucose cotransporter 2; SGLT2; Sodium-glucose transporter 2; Sodium/glucose cotransporter 2; Human SLC5A2; SGLT2
Product Gene Name
anti-SLC5A2 antibody
[Similar Products]
Product Synonym Gene Name
SGLT2[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P31639
Species Reactivity
Gibbon, Gorilla, Horse, Human, Rat
Predicted Reactivity: Monkey, Mouse, Bat, Bovine, Hamster (at least 90% immunogen sequence identity)
Specificity
Human SLC5A2. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Purity/Purification
Immunoaffinity Purified
Form/Format
PBS, 0.1% sodium azide.
Concentration
1 mg/ml (lot specific)
Immunogen Description
Synthetic 17 amino acid peptide from C-terminus of human SLC5A2. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Rat, Elephant, Horse (100%); Marmoset, Mouse, Hamster, Bat, Bovine (94%); Dog (88%).
Immunogen Type
Synthetic peptide
Immunogen
SLC5A2 / SGLT2 antibody was raised against synthetic 17 amino acid peptide from C-terminus of human SLC5A2. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Rat, Elephant, Horse (100%); Marmoset, Mouse, Hamster, Bat, Bovine (94%); Dog (88%); Panda, Rabbit (82%).
Antigen Modification
C-Terminus
Preparation and Storage
Long term: -70 degree C; Short term: +4 degree C
Other Notes
Small volumes of anti-SLC5A2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-SLC5A2 antibody
Subfamily:-Solute:sodium-symporter">Family: Transporter
Subfamily: Solute:sodium symporter
Applications Tested/Suitable for anti-SLC5A2 antibody
Immunohistochemistry (IHC - Paraffin)
Application Notes for anti-SLC5A2 antibody
IHC-P (20 ug/ml)
Immunohistochemistry (IHC) of anti-SLC5A2 antibody
Anti-SLC5A2 antibody IHC of human kidney, collecting duct. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
NCBI/Uniprot data below describe general gene information for SLC5A2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_003032.1
[Other Products]
NCBI GenBank Nucleotide #
NM_003041.3
[Other Products]
UniProt Primary Accession #
P31639
[Other Products]
UniProt Secondary Accession #
A2RRD2[Other Products]
UniProt Related Accession #
P31639[Other Products]
Molecular Weight
49,357 Da
NCBI Official Full Name
sodium/glucose cotransporter 2
NCBI Official Synonym Full Names
solute carrier family 5 (sodium/glucose cotransporter), member 2
NCBI Official Symbol
SLC5A2??[Similar Products]
NCBI Official Synonym Symbols
SGLT2
??[Similar Products]
NCBI Protein Information
sodium/glucose cotransporter 2; Na(+)/glucose cotransporter 2; solute carrier family 5 member 2; low affinity sodium-glucose cotransporter; solute carrier family 5 (sodium/glucose transporter), member 2
UniProt Protein Name
Sodium/glucose cotransporter 2
UniProt Synonym Protein Names
Low affinity sodium-glucose cotransporter; Solute carrier family 5 member 2
Protein Family
Sodium/glucose cotransporter
UniProt Gene Name
SLC5A2??[Similar Products]
UniProt Synonym Gene Names
SGLT2; Na(+)/glucose cotransporter 2??[Similar Products]
UniProt Entry Name
SC5A2_HUMAN
NCBI Summary for SLC5A2
This gene encodes a member of the sodium glucose cotransporter family which are sodium-dependent glucose transport proteins. The encoded protein is the major cotransporter involved in glucose reabsorption in the kidney. Mutations in this gene are associated with renal glucosuria. [provided by RefSeq, Sep 2009]
UniProt Comments for SLC5A2
SLC5A2: Sodium-dependent glucose transporter. Has a Na(+) to glucose coupling ratio of 1:1. Defects in SLC5A2 are the cause of renal glucosuria (GLYS1). GLYS1 is an autosomal recessive disorder characterized by a normal fasting serum glucose concentration and persistent isolated glucosuria, with a normal glucose tolerance test. Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
Protein type: Transporter, SLC family; Membrane protein, integral; Transporter; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 16p11.2
Cellular Component: integral to membrane; plasma membrane
Molecular Function: low-affinity glucose:sodium symporter activity
Biological Process: transport; carbohydrate metabolic process; sodium ion transport; glucose transport; transmembrane transport
Disease: Renal Glucosuria
Research Articles on SLC5A2
1. A single dose of canagliflozin, a sodium glucose co-transporter 2 inhibitor, 300 mg reduced both fasting and postprandial PG.
Precautions
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Disclaimer
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