Product Name
FTCD, cDNA Clone
Full Product Name
FTCD cDNA Clone
Product Gene Name
FTCD cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
ATGTCCCAGC TGGTGGAATG CGTCCCCAAC TTTTCGGAGG GGAAGAACCA GGAGGTGATC GACGCCATCT CTGGAGCCAT CACACAGACC CCGGGCTGCG TGCTGCTGGA TGTGGACGCA GGCCCTTCCA CCAACCGCAC CGTGTACACC TTCGTGGGGC CGCCGGAGTG CGTGGTGGAG GGGGCCCTCA ACGCTGCCCG GGTAGCTTCC CGACTTATCG ACATGAGCAG GCACCAAGGA GAGCACCCCC GCATGGGGGC CCTAGACGTC TGCCCCTTCA TCCCCGTGAG GGGCGTCAGC GTGGATGAGT GTGTGCTCTG CGCCCAGGCC TTTGGCCAGA GGCTGGCAGA GGAGCTGGAC GTGCCAGTTT ACCTGTACGG CGAGGCAGCC AGGATGGACA GTCGCCGGAC CCTGCCGGCC ATCCGGGCCG GGGAGTACGA GGCCCTCCCT AAGAAGCTCC AGCAGGCCGA CTGGGCGCCC GACTTTGGTC CCAGCTCCTT TGTCCCCAGT TGGGGGGCCA CGGCCACGGG GGCGAGGAAG TTCCTCATTG CTTTTAACAT CAACCTGCTC GGCACAAAGG AGCAAGCCCA CCGCATCGCG CTCAACCTGC GGGAGCAGGG CCGCGGGAAG GACCAGCCAG GACGTCTGAA GAAAGTTCAG GGCATTGGCT GGTACCTGGA TGAGAAGAAC CTGGCTCAGG TGTCCACCAA TCTTCTGGAC TTTGAGGTCA CGGCACTGCA CACGGTCTAC GAGGAGACCT GCCGAGAAGC ACAGGAGCTG AGCCTCCCAG TGGTGGGCTC ACAGCTGGTG GGCCTGGTGC CCCTGAAGGC TCTGCTGGAT GCGGCCGCCT TCTACTGCGA GAAGGAGAAC CTCTTCATCC TGGAGGAGGA GCAGCGGATC AGGCTGGTGG TGAGCCGGCT GGGCCTGGAC TCCCTGTGCC CCTTCAGCCC TAAGGAGCGG ATCATCGAGT ACCTGGTCCC TGAGCGCGGG CCTGAGCGAG GCCTGGGCAG CAAGTCCCTG CGCGCCTTCG TGGGGGAGGT GGGTGCCCGC TCTGCGGCCC CCGGGGGCGG CTCGGTGGCG GCGGCCGCTG CGGCCATGGG TGCGGCGCTG GGCTCCATGG TGGGCCTCAT GACCTACGGG CGGCGCCAAT TCCAGTCCCT GGACACGACG ATGCGGCGCC TGATCCCGCC CTTCCGCGAG GCTTCGGCCA AGCTAACCAC GCTGGTGGAT GCCGACGCCG AGGCCTTCAC CGCCTACCTG GAAGCAATGA GGCTCCCCAA GAACACACCT GAGGAAAAGG ACAGGCGCAC GGCGGCCCTA CAGGAGGGTC TGAGGCGGGC AGTCTCTGTG CCGCTGACGC TGGCGGAGAC GGTGGCCTCG CTGTGGCCGG CGCTGCAGGA ACTGGCCCGG TGTGGGAACC TGGCCTGCCG GTCAGACCTC CAGGTGGCGG CCAAAGCCCT GGAGATGGGC GTGTTTGGCG CATATTTCAA CGTGCTCATC AACCTGAGGG ACATCACAGA CGAGGCATTT AAGGACCAGA TCCACCATCG TGTTTCCAGC CTCCTGCAGG AAGCCAAGAC CCAGGCTGCA CTGGTGCTGG ACTGCTTGGA GACCCGGCAG GAGTGA
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of FTCD cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for FTCD. It may not necessarily be applicable to this product.
NCBI Accession #
BC052248
[Other Products]
UniProt Secondary Accession #
Q86V03; Q9HCT4; Q9HCT5; Q9HCT6; Q9UHJ2; B9EGD0[Other Products]
UniProt Related Accession #
O95954[Other Products]
Molecular Weight
16,503 Da
NCBI Official Full Name
Homo sapiens formiminotransferase cyclodeaminase, mRNA
NCBI Official Synonym Full Names
formimidoyltransferase cyclodeaminase
NCBI Official Symbol
FTCD??[Similar Products]
NCBI Official Synonym Symbols
LCHC1
??[Similar Products]
NCBI Protein Information
formimidoyltransferase-cyclodeaminase
UniProt Protein Name
Formimidoyltransferase-cyclodeaminase
UniProt Synonym Protein Names
Formiminotransferase-cyclodeaminase; FTCD; LCHC1Including the following 2 domains:Glutamate formimidoyltransferase (EC:2.1.2.5)Alternative name(s):Glutamate formiminotransferase; Glutamate formyltransferase
Protein Family
Formimidoyltransferase-cyclodeaminase
UniProt Gene Name
FTCD??[Similar Products]
UniProt Synonym Gene Names
FTCD??[Similar Products]
UniProt Entry Name
FTCD_HUMAN
NCBI Summary for FTCD
The protein encoded by this gene is a bifunctional enzyme that channels 1-carbon units from formiminoglutamate, a metabolite of the histidine degradation pathway, to the folate pool. Mutations in this gene are associated with glutamate formiminotransferase deficiency. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Dec 2009]
UniProt Comments for FTCD
FTCD: Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool. Defects in FTCD are the cause of glutamate formiminotransferase deficiency (FIGLU-URIA); also known as formiminoglutamicaciduria (FIGLU-uria). It is an autosomal recessive disorder. Features of a severe phenotype, include elevated levels of formiminoglutamate (FIGLU) in the urine in response to histidine administration, megaloblastic anemia, and mental retardation. Features of a mild phenotype include high urinary excretion of FIGLU in the absence of histidine administration, mild developmental delay, and no hematological abnormalities. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Amino Acid Metabolism - histidine; Cofactor and Vitamin Metabolism - one carbon pool by folate; EC 2.1.2.5; EC 4.3.1.4; Lyase; Methyltransferase
Chromosomal Location of Human Ortholog: 21q22.3
Cellular Component: cytoplasm; cytosol; endoplasmic reticulum; ER-Golgi intermediate compartment; Golgi apparatus; Golgi membrane; smooth endoplasmic reticulum membrane
Molecular Function: formimidoyltetrahydrofolate cyclodeaminase activity; formimidoyltransferase activity; microtubule binding; protein binding
Biological Process: folic acid and derivative metabolic process; histidine catabolic process
Disease: Formiminotransferase Deficiency
Research Articles on FTCD
1. FTCD is a positive regulator of the hypoxia-HIF signaling pathway and has an important role in cell proliferation, metabolism and migration in HepG2 cells
Precautions
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Disclaimer
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