Anti -FTCD, NT (Formimidoyltransferase-cyclodeaminase, Formiminotransferase-cyclodeaminase, LCHC1)

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 21; NC_000021.8 (47556065..47575499, complement). Location: 21q22.3

Polyclonal

Goat

Recognizes human FTCD. Species sequence homology: Mouse.

Affinity Purified
Purified by immunoaffinity chromatography.

Supplied as a liquid in TBS, 0.5% BSA, 0.02% sodium azide.

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Small volumes of anti-FTCD antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

FTCD is a bifunctional enzyme that channels 1-carbon units from formiminoglutamate, a metabolite of the histidine degradation pathway, to the folate pool.

Antibodies; Abs to Golgi Proteins

ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)

Suitable for use in ELISA, Western Blot and Immunohistochemistry.
Dilution: ELISA: 1:64,000
Western Blot: 0.03-0.5ug/ml
Immunohistochemistry (Formalin-fixed, paraffin-embedded): 3.75ug/ml

58,927 Da[Similar Products]

formimidoyltransferase cyclodeaminase

formimidoyltransferase-cyclodeaminase; formiminotransferase cyclodeaminase; formiminotransferase-cyclodeaminase

Formimidoyltransferase-cyclodeaminase

FTCD??[Similar Products]

FTCD_HUMAN

The protein encoded by this gene is a bifunctional enzyme that channels 1-carbon units from formiminoglutamate, a metabolite of the histidine degradation pathway, to the folate pool. Mutations in this gene are associated with glutamate formiminotransferase deficiency. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Dec 2009]

Function: Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool.Binds and promotes bundling of vimentin filaments originating from the Golgi

By similarity.

Catalytic activity: 5-formimidoyltetrahydrofolate + L-glutamate = tetrahydrofolate + N-formimidoyl-L-glutamate.5-formyltetrahydrofolate + L-glutamate = tetrahydrofolate + N-formyl-L-glutamate.5-formimidoyltetrahydrofolate = 5,10-methenyltetrahydrofolate + NH3.

Cofactor: Pyridoxal phosphate.

Pathway: Amino-acid degradation; L-histidine degradation into L-glutamate; L-glutamate from N-formimidoyl-L-glutamate (transferase route): step 1/1.One-carbon metabolism; tetrahydrofolate interconversion.

Subunit structure: Homooctamer, including four polyglutamate s. The subunits are arranged as a tetramer of dimers, and form a planar ring-shaped structure

By similarity.

Subcellular location: Cytoplasm ? cytoskeleton ? microtubule organizing center ? centrosome ? centriole. Golgi apparatus

By similarity. Note: More abundantly located around the mother centriole. Ref.5

Involvement in disease: Glutamate formiminotransferase deficiency (FIGLU-URIA) [MIM:229100]: Autosomal recessive disorder. Features of a severe phenotype, include elevated levels of formiminoglutamate (FIGLU) in the urine in response to histidine administration, megaloblastic anemia, and mental retardation. Features of a mild phenotype include high urinary excretion of FIGLU in the absence of histidine administration, mild developmental delay, and no hematological abnormalities.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.6

Sequence similarities: In the C-terminal section; belongs to the cyclodeaminase/cyclohydrolase family.In the N-terminal section; belongs to the formiminotransferase family.

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