FGF23; ADHR; FGFN; HPDR2; HYPF; PHPTC

For Research Use Only. Not for use in diagnostic procedures.

Human Cells

> 95% by SDS-PAGE.

Lyophilized from a 0.2 muM filtered solution of 20mM PB, 150mM NaCl, 1mM EDTA, 2mM DTT, pH 7.4.

Store the lyophilized protein at-20 degree C to-80 degree C for long term.
After reconstitution, the protein solution is stable at-20 degree C for 3 months, at 2-8 degree C for up to 1 week.

Small volumes of FGF23 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Description: Recombinant Human FGF23 Protein is produced by human cell expression system. The target protein is expressed with sequence (Tyr25-Ile251) of human FGF23 (Accession #Q9GZV9) fused with a 6xHis tag at the C-terminus.
Background: This protein belongs a member of the fibroblast growth factor family of proteins, which possess broad mitogenic and cell survival activities and are involved in a variety of biological processes. The product of this gene regulates phosphate homeostasis and transport in the kidney. The full-length, functional protein may be deactivated via cleavage into N-terminal and C-terminal chains. Mutation of this cleavage site causes autosomal dominant hypophosphatemic rickets (ADHR). Mutations in this gene are also associated with hyperphosphatemic familial tumoral calcinosis (HFTC).

27,954 Da

fibroblast growth factor 23

fibroblast growth factor 23

Fibroblast growth factor 23

HYPF; FGF-23??[Similar Products]

This gene encodes a member of the fibroblast growth factor family of proteins, which possess broad mitogenic and cell survival activities and are involved in a variety of biological processes. The product of this gene regulates phosphate homeostasis and transport in the kidney. The full-length, functional protein may be deactivated via cleavage into N-terminal and C-terminal chains. Mutation of this cleavage site causes autosomal dominant hypophosphatemic rickets (ADHR). Mutations in this gene are also associated with hyperphosphatemic familial tumoral calcinosis (HFTC). [provided by RefSeq, Feb 2013]

Regulator of phosphate homeostasis. Inhibits renal tubular phosphate transport by reducing SLC34A1 levels. Upregulates EGR1 expression in the presence of KL (). Acts directly on the parathyroid to decrease PTH secretion (). Regulator of vitamin-D metabolism. Negatively regulates osteoblast differentiation and matrix mineralization.

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