Product Name
FGF23, Recombinant Protein
Popular Item
Full Product Name
FGF23 protein
Product Synonym Names
FGF-23 protein; FGF-23; FGF23; FGF 23; Fibroblast Growth Factor-23 protein; FGF 23 protein
Product Gene Name
FGF23 recombinant protein
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
Region of FGF23 protein correspond ing to amino acids MYPNASPLLG SSWGGLIHLY TATARNSYHL QIHKNGHVDG APHQTIYSAL MIRSEDAGFV VITGVMSRRY LCMDFRGNIF GSHYFDPENC RFQHQTLENG YDVYHSPQYH FLVSLGRAKR AFLPGMNPPP YSQFLSRRNE IPLIHFNTPI PRRHTRSAED DSERDPLNVL KPRARMTPAP ASCSQELPSA EDNSPMASDP LGVVRGGRVN THAGGTGPEG CRPFAKFI.
3D Structure
ModBase 3D Structure for Q9GZV9
Purity/Purification
> 95% pure
Form/Format
Lyophilized powder from 10mM sodium acetate, pH 6.0 plus 0.1M arginine. Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.5 mg/ml. Do not vortex.
Concentration
20ug lyophilized (lot specific)
Contaminants
Endotoxin: <0.1ng/ug
Biological Significance
The FGF family plays a central role during prenatal development and postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. FGF23, FGF21 and FGF19 constitute an atypical FGF subfamily whose ligands act as circulating hormones and require the participation of a Klotho protein as a co-receptor for their signaling. FGF23 is a bone-derived hormone that acts in the kidney to regulate phosphate homeostasis and vitamin D metabolism. The signaling receptor for FGF23, a Klotho-FGFR1 (IIIc) complex, is an essential regulator of the renal sodium phosphate co-transporter and key vitamin D-metabolizing enzymes CYP27B1 and CYP24A1.
Biohazrd
Use appropriate laboratory precautions when handling this product.
Preparation and Storage
Ships ambient or refrigerated. Upon receipt store at 4°C short term; -20°C to -80°C long term. Avoid repeat freeze-thaws.
Other Notes
Small volumes of FGF23 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
FGF23 recombinant protein
Purified recombinant Human FGF23 protein
Product Categories/Family for FGF23 recombinant protein
Cytokines & Growth Factors
Applications Tested/Suitable for FGF23 recombinant protein
User optimized
NCBI/Uniprot data below describe general gene information for FGF23. It may not necessarily be applicable to this product.
NCBI Accession #
EAW88848.1
[Other Products]
UniProt Primary Accession #
Q9GZV9
[Other Products]
UniProt Secondary Accession #
Q4V758[Other Products]
UniProt Related Accession #
Q9GZV9[Other Products]
Molecular Weight
22.5 kDa
NCBI Official Full Name
fibroblast growth factor 23
NCBI Official Synonym Full Names
fibroblast growth factor 23
NCBI Official Symbol
FGF23??[Similar Products]
NCBI Official Synonym Symbols
ADHR; FGFN; HYPF; HPDR2; PHPTC
??[Similar Products]
NCBI Protein Information
fibroblast growth factor 23
UniProt Protein Name
Fibroblast growth factor 23
UniProt Synonym Protein Names
Phosphatonin; Tumor-derived hypophosphatemia-inducing factor
Protein Family
Fibroblast growth factor
UniProt Gene Name
FGF23??[Similar Products]
UniProt Synonym Gene Names
HYPF; FGF-23??[Similar Products]
UniProt Entry Name
FGF23_HUMAN
NCBI Summary for FGF23
This gene encodes a member of the fibroblast growth factor family of proteins, which possess broad mitogenic and cell survival activities and are involved in a variety of
biological processes. The product of this gene regulates phosphate homeostasis and transport in the kidney. The full-length, functional protein may be deactivated via cleavage into N-terminal and C-terminal chains. Mutation of this cleavage site causes autosomal dominant hypophosphatemic rickets (ADHR). Mutations in this gene are also associated with hyperphosphatemic familial tumoral calcinosis (HFTC). [provided by RefSeq, Feb 2013]
UniProt Comments for FGF23
FGF23: Regulator of phosphate homeostasis. Inhibits renal tubular phosphate transport by reducing SLC34A1 levels. Upregulates EGR1 expression in the presence of KL. Acts directly on the parathyroid to decrease PTH secretion. Regulator of vitamin-D metabolism. Negatively regulates osteoblast differentiation and matrix mineralization. Defects in FGF23 are the cause of autosomal dominant hypophosphataemic rickets (ADHR). ADHR is characterized by low serum phosphorus concentrations, rickets, osteomalacia, leg deformities, short stature, bone pain and dental abscesses. Defects in FGF23 are a cause of hyperphosphatemic familial tumoral calcinosis (HFTC). HFTC is a severe autosomal recessive metabolic disorder that manifests with hyperphosphatemia and massive calcium deposits in the skin and subcutaneous tissues. Belongs to the heparin-binding growth factors family.
Protein type: Secreted, signal peptide; Secreted; Cytokine
Chromosomal Location of Human Ortholog: 12p13.3
Cellular Component: extracellular space; extracellular region
Molecular Function: growth factor activity; type 1 fibroblast growth factor receptor binding
Biological Process: epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; nerve growth factor receptor signaling pathway; negative regulation of hormone secretion; positive regulation of transcription, DNA-dependent; phosphate metabolic process; negative regulation of bone mineralization; cellular phosphate ion homeostasis; insulin receptor signaling pathway; innate immune response; negative regulation of osteoblast differentiation; phosphate ion homeostasis; cell differentiation; vitamin D catabolic process
Disease: Hypophosphatemic Rickets, Autosomal Dominant
Research Articles on FGF23
1. the influence of FGF23 on the cardiovascular system and its role in the pathogenesis of hypertension thus this will be the main aspect of our review article.
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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