Product Name
FGF23, cDNA Clone
Full Product Name
FGF23 cDNA Clone
Product Gene Name
FGF23 cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atgttggggg cccgcctcag gctctgggtc tgtgccttgt gcagcgtctg cagcatgagc gtcctcagag cctatcccaa tgcctcccca ctgctcggct ccagctgggg tggcctgatc cacctgtaca cagccacagc caggaacagc taccacctgc agatccacaa gaatggccat gtggatggcg caccccatca gaccatctac agtgccctga tgatcagatc agaggatgct ggctttgtgg tgattacagg tgtgatgagc agaagatacc tctgcatgga tttcagaggc aacatttttg gatcacacta tttcgacccg gagaactgca ggttccaaca ccagacgctg gaaaacgggt acgacgtcta ccactctcct cagtatcact tcctggtcag tctgggccgg gcgaagagag ccttcctgcc aggcatgaac ccacccccgt actcccagtt cctgtcccgg aggaacgaga tccccctaat tcacttcaac acccccatac cacggcggca cacccggagc gccgaggacg actcggagcg ggaccccctg aacgtgctga agccccgggc ccggatgacc ccggccccgg cctcctgttc acaggagctc ccgagcgccg aggacaacag cccgatggcc agtgacccat taggggtggt caggggcggt cgagtgaaca cgcacgctgg gggaacgggc ccggaaggct gccgcccctt cgccaagttc atctag
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of FGF23 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for FGF23. It may not necessarily be applicable to this product.
NCBI Accession #
BC069333
[Other Products]
UniProt Secondary Accession #
Q4V758[Other Products]
UniProt Related Accession #
Q9GZV9[Other Products]
Molecular Weight
27,954 Da
NCBI Official Full Name
Homo sapiens fibroblast growth factor 23, mRNA
NCBI Official Synonym Full Names
fibroblast growth factor 23
NCBI Official Symbol
FGF23??[Similar Products]
NCBI Official Synonym Symbols
ADHR; FGFN; HYPF; HPDR2; PHPTC
??[Similar Products]
NCBI Protein Information
fibroblast growth factor 23
UniProt Protein Name
Fibroblast growth factor 23
UniProt Synonym Protein Names
Phosphatonin; Tumor-derived hypophosphatemia-inducing factor
Protein Family
Fibroblast growth factor
UniProt Gene Name
FGF23??[Similar Products]
UniProt Synonym Gene Names
HYPF; FGF-23??[Similar Products]
UniProt Entry Name
FGF23_HUMAN
NCBI Summary for FGF23
This gene encodes a member of the fibroblast growth factor family of proteins, which possess broad mitogenic and cell survival activities and are involved in a variety of
biological processes. The product of this gene regulates phosphate homeostasis and transport in the kidney. The full-length, functional protein may be deactivated via cleavage into N-terminal and C-terminal chains. Mutation of this cleavage site causes autosomal dominant hypophosphatemic rickets (ADHR). Mutations in this gene are also associated with hyperphosphatemic familial tumoral calcinosis (HFTC). [provided by RefSeq, Feb 2013]
UniProt Comments for FGF23
FGF23: Regulator of phosphate homeostasis. Inhibits renal tubular phosphate transport by reducing SLC34A1 levels. Upregulates EGR1 expression in the presence of KL. Acts directly on the parathyroid to decrease PTH secretion. Regulator of vitamin-D metabolism. Negatively regulates osteoblast differentiation and matrix mineralization. Defects in FGF23 are the cause of autosomal dominant hypophosphataemic rickets (ADHR). ADHR is characterized by low serum phosphorus concentrations, rickets, osteomalacia, leg deformities, short stature, bone pain and dental abscesses. Defects in FGF23 are a cause of hyperphosphatemic familial tumoral calcinosis (HFTC). HFTC is a severe autosomal recessive metabolic disorder that manifests with hyperphosphatemia and massive calcium deposits in the skin and subcutaneous tissues. Belongs to the heparin-binding growth factors family.
Protein type: Secreted, signal peptide; Cytokine; Secreted
Chromosomal Location of Human Ortholog: 12p13.3
Cellular Component: extracellular region; extracellular space; Golgi lumen
Molecular Function: 1-phosphatidylinositol-3-kinase activity; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; protein-tyrosine kinase activity; Ras guanyl-nucleotide exchange factor activity
Biological Process: fibroblast growth factor receptor signaling pathway; MAPKKK cascade; negative regulation of bone mineralization; negative regulation of hormone secretion; negative regulation of osteoblast differentiation; phosphate ion homeostasis; phosphoinositide-mediated signaling; regulation of phosphoinositide 3-kinase cascade; vitamin D catabolic process
Disease: Hypophosphatemic Rickets, Autosomal Dominant
Research Articles on FGF23
1. Data suggest that intraperitoneal injection of recombinant Fgf23 extends time to exhaustion of mice on treadmill and reduces exercise-induced production of reactive oxygen species in skeletal muscle.
Precautions
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Disclaimer
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