Full Product Name
Anti-CRX Rabbit pAb
Product Synonym Names
Cone rod homeobox; CORD 2; CRD; CRX; LCA7; OTX3
Product Gene Name
anti-CRX antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for O43186
Specificity
CRX Antibody detects endogenous levels of total CRX
Purity/Purification
Affinity Chromatography
Form/Format
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Immunogen
A synthesized peptide derived from human CRX
Preparation and Storage
Store at 4 degree C for short term.
Store at-20 degree C for long term.
Avoid freeze/thaw cycle.
Other Notes
Small volumes of anti-CRX antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CRX antibody
Binds and transactivates the sequence 5'-TAATC[CA]-3' which is found upstream of several photoreceptor-specific genes, including the opsin genes. Acts synergistically with other transcription factors, e.g. NRL and RX, to regulate photoreceptor cell-specific gene transcription. Essential for the maintenance of mammalian photoreceptors.
Applications Tested/Suitable for anti-CRX antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-CRX antibody
WB: 1:500-1:2000
IHC: 1:50-1:200
Western Blot (WB) of anti-CRX antibody
Western blot analysis of CRX expression in Y79 cell lysate.
NCBI/Uniprot data below describe general gene information for CRX. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000545.1
[Other Products]
NCBI GenBank Nucleotide #
NM_000554.5
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UniProt Primary Accession #
O43186
[Other Products]
UniProt Secondary Accession #
Q0QD45[Other Products]
UniProt Related Accession #
O43186[Other Products]
NCBI Official Full Name
cone-rod homeobox protein
NCBI Official Synonym Full Names
cone-rod homeobox
NCBI Official Symbol
CRX??[Similar Products]
NCBI Official Synonym Symbols
CRD; LCA7; OTX3; CORD2
??[Similar Products]
NCBI Protein Information
cone-rod homeobox protein
UniProt Protein Name
Cone-rod homeobox protein
Protein Family
Cone-rod homeobox protein
UniProt Gene Name
CRX??[Similar Products]
UniProt Synonym Gene Names
CORD2??[Similar Products]
NCBI Summary for CRX
The protein encoded by this gene is a photoreceptor-specific transcription factor which plays a role in the differentiation of photoreceptor cells. This homeodomain protein is necessary for the maintenance of normal cone and rod function. Mutations in this gene are associated with photoreceptor degeneration, Leber congenital amaurosis type III and the autosomal dominant cone-rod dystrophy 2. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]
UniProt Comments for CRX
Transcription factor that binds and transactivates the sequence 5'-TAATC[CA]-3' which is found upstream of several photoreceptor-specific genes, including the opsin genes. Acts synergistically with other transcription factors, such as NRL, RORB and RAX, to regulate photoreceptor cell-specific gene transcription. Essential for the maintenance of mammalian photoreceptors.
Research Articles on CRX
1. CRX mutations are associated with a variety of clinical phenotypes, including an *****-onset macular dystrophy that simulates benign concentric annular macular dystrophy with a bull's eye macular lesion and fairly well preserved visual acuity.
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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