Product Name
SGCA, cDNA Clone
Full Product Name
SGCA cDNA Clone
Product Gene Name
SGCA cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atggctgaga cactcttctg gactcctctc ctcgtggttc tcctggcagg gctgggggac accgaggccc agcagaccac gctacaccca cttgtgggcc gtgtctttgt gcacaccttg gaccatgaga cgtttctgag ccttcctgag catgtcgctg tcccacccgc tgtccacatc acctaccacg cccacctcca gggacaccca gacctgcccc ggtggctccg ctacacccag cgcagccccc accaccctgg cttcctctac ggctctgcca ccccagaaga tcgtgggctc caggtcattg aggtcacagc ctacaatcgg gacagctttg ataccactcg gcagaggctg gtgctggaga ttggggaccc agaaggcccc ctgctgccat accaagccga gttcctggtg cgcagccacg atgcggagga ggtgctgccc tcaacacctg ccagccgctt cctctcagcc ttggggggac tctgggagcc cggagagctt cagctgctca acgtcacctc tgccttggac cgtgggggcc gtgtccccct tcccattgag ggccgaaaag aaggggtata cattaaggtg ggttctgcct cacctttttc tacttgcctg aagatggtgg catcccccga tagccacgcc cgctgtgccc agggccagcc tccacttctg tcttgctacg acaccttggc accccacttc cgcgttgact ggtgcaatgt gaccctggtg gataagtcag tgccggagcc tgcagatgag gtgcccaccc caggtgatgg gatcctggag catgacccgt tcttctgccc acccactgag gccccagacc gtgacttctt ggtggatgct ctggtcaccc tcctggtgcc cctgctggtg gccctgcttc tcaccttgct gctggcctat gtcatgtgct gccggcggga gggaaggctg aagagagacc tggctacctc cgacatccag atggtccacc actgcaccat ccacgggaac acagaggagc tgcggcagat ggcggccagc cgcgaggtgc cccggccact ctccaccctg cccatgttca atgtgcacac aggtgagcgg ctgcctcccc gcgtggacag cgcccaggtg cccctcattc tggaccagca ctga
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of SGCA cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for SGCA. It may not necessarily be applicable to this product.
NCBI Accession #
BC025702
[Other Products]
UniProt Secondary Accession #
Q13710; Q13712; A6NEB8; A8K3K7[Other Products]
UniProt Related Accession #
Q16586[Other Products]
Molecular Weight
29,354 Da
NCBI Official Full Name
Homo sapiens sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein), mRNA
NCBI Official Synonym Full Names
sarcoglycan alpha
NCBI Official Symbol
SGCA??[Similar Products]
NCBI Official Synonym Symbols
ADL; DAG2; 50DAG; DMDA2; LGMD2D; SCARMD1; adhalin
??[Similar Products]
NCBI Protein Information
alpha-sarcoglycan
UniProt Protein Name
Alpha-sarcoglycan
UniProt Synonym Protein Names
50 kDa dystrophin-associated glycoprotein; 50DAG; Adhalin; Dystroglycan-2
Protein Family
Alpha-sarcoglycan
UniProt Gene Name
SGCA??[Similar Products]
UniProt Synonym Gene Names
ADL; DAG2; Alpha-SG; 50DAG??[Similar Products]
UniProt Entry Name
SGCA_HUMAN
NCBI Summary for SGCA
This gene encodes a component of the dystrophin-glycoprotein complex (DGC), which is critical to the stability of muscle fiber membranes and to the linking of the actin cytoskeleton to the extracellular matrix. Its expression is thought to be restricted to striated muscle. Mutations in this gene result in type 2D autosomal recessive limb-girdle muscular dystrophy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
UniProt Comments for SGCA
SGCA: Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. Defects in SGCA are the cause of limb-girdle muscular dystrophy type 2D (LGMD2D); also known as Duchenne- like muscular dystrophy autosomal recessive type 2 or severe childhood autosomal recessive muscular dystrophy (SCARMD). LGMD2D is an autosomal recessive degenerative myopathy characterized by progressive muscle wasting from early childhood with loss of independent ambulation by teenage years. Muscle biopsy shows necrosis, decreased immunostaining for alpha sarcoglycan, and adhalin deficiency. The phenotype is less severe than LGMD2C. Belongs to the sarcoglycan alpha/epsilon family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 17q21
Cellular Component: dystrophin-associated glycoprotein complex; sarcoglycan complex
Molecular Function: protein binding
Biological Process: muscle contraction; muscle development
Disease: Muscular Dystrophy, Limb-girdle, Type 2d
Research Articles on SGCA
1. B4GAT1 is involved in the initiation of the LARGE-dependent repeating disaccharide that is necessary for extracellular matrix protein binding to O-mannosylated alpha-dystroglycan.
Precautions
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Disclaimer
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