Full Product Name
Dicer Antibody
Product Synonym Names
DICER1; DCR1; Dicer; Dicer 1; ribonuclease type III; Endoribonuclease Dicer; HERNA; Helicase-moi; MNG1; Helicase with RNase motif; Dicer1; Dcr-1 homolog; Helicase MOI; K12H4.8-LIKE; KIAA0928
Product Gene Name
anti-Dicer antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9UPY3
Specificity
Dicer Antibody detects endogenous levels of total Dicer
Form/Format
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1.0mg/mL (lot specific)
Immunogen
A synthesized peptide derived from human Dicer
Preparation and Storage
Store at -20 degree C
Other Notes
Small volumes of anti-Dicer antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-Dicer antibody
Total protein Ab
Applications Tested/Suitable for anti-Dicer antibody
Western Blot (WB)
Application Notes for anti-Dicer antibody
Western Blot: 1:1000-3000
Western Blot (WB) of anti-Dicer antibody
Western blot analysis Dicer using RAW264.7 whole cell lysates
NCBI/Uniprot data below describe general gene information for Dicer. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001182502.1
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NCBI GenBank Nucleotide #
NM_001195573.1
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UniProt Primary Accession #
Q9UPY3
[Other Products]
UniProt Secondary Accession #
O95943; Q9UQ02; A7E2D3; B3KRG4; E0AD28[Other Products]
UniProt Related Accession #
Q9UPY3[Other Products]
Molecular Weight
92,726 Da
NCBI Official Full Name
endoribonuclease Dicer isoform 2
NCBI Official Synonym Full Names
dicer 1, ribonuclease III
NCBI Official Symbol
DICER1??[Similar Products]
NCBI Official Synonym Symbols
DCR1; MNG1; Dicer; HERNA; RMSE2; Dicer1e; K12H4.8-LIKE
??[Similar Products]
NCBI Protein Information
endoribonuclease Dicer
UniProt Protein Name
Endoribonuclease Dicer
UniProt Synonym Protein Names
Helicase with RNase motif; Helicase MOI
Protein Family
Dicer-like protein
UniProt Gene Name
DICER1??[Similar Products]
UniProt Synonym Gene Names
DICER; HERNA; KIAA0928; Helicase MOI??[Similar Products]
UniProt Entry Name
DICER_HUMAN
NCBI Summary for Dicer
This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010]
UniProt Comments for Dicer
DICER1: a cytoplasmic type-III RNase that plays a central role in RNA interference (RNAi) pathways to produce the active small RNAs that represses gene expression. Possesses a DEAD box RNA helicase motif in its amino terminus and a dsRNA-binding motif in the carboxy terminus. Dicer, along with Ago2 andTRBP, are the main components of the RNA-induced silencing complex (RISC). Fragile X syndrome repeats form RNA hairpins that are cut by Dicer but do not activate the interferon-inducible protein kinase, PKR. Four alternatively spliced isoforms have been described.
Protein type: Cell development/differentiation; EC 3.1.26.3; Helicase; RNA processing; RNA-binding; Ribonuclease
Chromosomal Location of Human Ortholog: 14q32.13
Cellular Component: cytoplasm; cytosol; nucleus
Molecular Function: deoxyribonuclease I activity; double-stranded RNA binding; endoribonuclease activity; protein binding; protein domain specific binding; ribonuclease III activity; siRNA binding
Biological Process: DNA fragmentation during apoptosis; miRNA-mediated gene silencing, miRNA loading onto RISC; miRNA-mediated gene silencing, production of miRNAs; myelin formation in the peripheral nervous system; negative regulation of transcription from RNA polymerase II promoter; nerve development; neurite morphogenesis; positive regulation of myelination; positive regulation of Schwann cell differentiation; pre-microRNA processing; RNA interference, conversion of ds siRNA to ss siRNA; RNA interference, production of siRNA; RNA interference, siRNA loading onto RISC; RNA interference, targeting of mRNA for destruction; RNA-mediated gene silencing
Disease: Goiter, Multinodular 1, With Or Without Sertoli-leydig Cell Tumors; Pleuropulmonary Blastoma; Rhabdomyosarcoma, Embryonal, 2
Research Articles on Dicer
1. DICER, DROSHA and DNA damage response RNAs act in the response to DNA damage after primary recognition of DNA lesions and, together with gammaH2AX, are essential for enabling the secondary recruitment of DDR factors and fuel the amplification of DDR signaling.
Precautions
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Disclaimer
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