Full Product Name
APRT Rabbit Polyclonal
Product Gene Name
anti-APRT antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Purity/Purification
>=95% as determined by SDS-PAGE
Immunogen Affinity Purified
Immunogen
Adenine phosphoribosyltransferase
Preparation and Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-APRT antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-APRT antibody
ELISA (EIA), Western Blot (WB)
NCBI/Uniprot data below describe general gene information for APRT. It may not necessarily be applicable to this product.
NCBI Accession #
AKI71908.1
[Other Products]
UniProt Secondary Accession #
Q3KP55; Q68DF9; G5E9J2[Other Products]
UniProt Related Accession #
P07741[Other Products]
Molecular Weight
14,557 Da
NCBI Official Full Name
APRT, partial
NCBI Official Synonym Full Names
adenine phosphoribosyltransferase
NCBI Official Symbol
APRT??[Similar Products]
NCBI Official Synonym Symbols
AMP; APRTD
??[Similar Products]
NCBI Protein Information
adenine phosphoribosyltransferase
UniProt Protein Name
Adenine phosphoribosyltransferase
Protein Family
Probable adenine phosphoribosyltransferase
UniProt Gene Name
APRT??[Similar Products]
UniProt Synonym Gene Names
APRT??[Similar Products]
UniProt Entry Name
APT_HUMAN
NCBI Summary for APRT
Adenine phosphoribosyltransferase belongs to the purine/pyrimidine phosphoribosyltransferase family. A conserved feature of this gene is the distribution of CpG dinucleotides. This enzyme catalyzes the formation of AMP and inorganic pyrophosphate from adenine and 5-phosphoribosyl-1-pyrophosphate (PRPP). It also produces adenine as a by-product of the polyamine biosynthesis pathway. A homozygous deficiency in this enzyme causes 2,8-dihydroxyadenine urolithiasis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for APRT
APRT: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. Defects in APRT are the cause of adenine phosphoribosyltransferase deficiency (APRTD); also known as 2,8-dihydroxyadenine urolithiasis. An enzymatic deficiency that can lead to urolithiasis and renal failure. Patients have 2,8-dihydroxyadenine (DHA) urinary stones. Belongs to the purine/pyrimidine phosphoribosyltransferase family.
Protein type: Transferase; EC 2.4.2.7; Nucleotide Metabolism - purine
Chromosomal Location of Human Ortholog: 16q24
Cellular Component: cytoplasm; cytosol; nucleoplasm
Molecular Function: adenine binding; adenine phosphoribosyltransferase activity; AMP binding
Biological Process: adenine salvage; cellular response to insulin stimulus; grooming behavior; lactation; purine salvage
Disease: Adenine Phosphoribosyltransferase Deficiency
Research Articles on APRT
1. A new mutation, p.Gln147X, in APRT gene, was found in a patient with adenine phosphoribosyltransferase deficiency.
Precautions
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Disclaimer
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