Product Name
AKAP9 / YOTIAO, Polyclonal Antibody
Full Product Name
Anti-AKAP9 / YOTIAO Antibody
Product Gene Name
anti-AKAP9 antibody
[Similar Products]
Product Synonym Gene Name
YOTIAO[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q99996
Species Reactivity
Human, Other
Purity/Purification
Affinity Purified
Concentration
100ug/200ul (lot specific)
Storage Buffer
Supplied at 0.5 mg/ml in Tris saline,0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
Preparation and Storage
This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Other Notes
Small volumes of anti-AKAP9 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-AKAP9 antibody
Western Blot (WB), ELISA (EIA)
NCBI/Uniprot data below describe general gene information for AKAP9. It may not necessarily be applicable to this product.
NCBI Accession #
NP_671714.1
[Other Products]
NCBI GenBank Nucleotide #
NM_147185.2
[Other Products]
UniProt Primary Accession #
Q99996
[Other Products]
UniProt Secondary Accession #
O14869; O43355; O94895; Q75N20; Q9UQH3; Q9UQQ4; Q9Y6B8; Q9Y6Y2; A4D1F0; A4D1F2; A4D1F4[Other Products]
UniProt Related Accession #
Q99996[Other Products]
Molecular Weight
455,423 Da
NCBI Official Full Name
A-kinase anchor protein 9 isoform 3
NCBI Official Synonym Full Names
A-kinase anchoring protein 9
NCBI Official Symbol
AKAP9??[Similar Products]
NCBI Official Synonym Symbols
LQT11; PRKA9; AKAP-9; CG-NAP; YOTIAO; AKAP350; AKAP450; PPP1R45; HYPERION; MU-RMS-40.16A
??[Similar Products]
NCBI Protein Information
A-kinase anchor protein 9
UniProt Protein Name
A-kinase anchor protein 9
UniProt Synonym Protein Names
A-kinase anchor protein 350 kDa; AKAP 350; hgAKAP 350; A-kinase anchor protein 450 kDa; AKAP 450; AKAP 120-like protein; Centrosome- and Golgi-localized PKN-associated protein
Protein Family
A-kinase anchor protein
UniProt Gene Name
AKAP9??[Similar Products]
UniProt Synonym Gene Names
AKAP350; AKAP450; KIAA0803; PRKA9??[Similar Products]
NCBI Summary for AKAP9
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. Alternate splicing of this gene results in at least two isoforms that localize to the centrosome and the Golgi apparatus, and interact with numerous signaling proteins from multiple signal transduction pathways. These signaling proteins include type II protein kinase A, serine/threonine kinase protein kinase N, protein phosphatase 1, protein phosphatase 2a, protein kinase C-epsilon and phosphodiesterase 4D3. [provided by RefSeq, Aug 2008]
UniProt Comments for AKAP9
AKAP9: Binds to type II regulatory subunits of protein kinase A. Scaffolding protein that assembles several protein kinases and phosphatases on the centrosome and Golgi apparatus. May be required to maintain the integrity of the Golgi apparatus. Isoform 4 is associated with the N-methyl-D-aspartate receptor and is specifically found in the neuromuscular junction (NMJ) as well as in neuronal synapses, suggesting a role in the organization of postsynaptic specializations. Defects in AKAP9 are the cause of long QT syndrome type 11 (LQT11). Long QT syndromes are heart disorders characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to excercise or emotional stress. They can present with a sentinel event of sudden cardiac death in infancy. 6 isoforms of the human protein are produced by alternative splicing.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 7q21.2
Cellular Component: centrosome; cis-Golgi network; cytoskeleton; cytosol; Golgi apparatus; Golgi stack; intracellular membrane-bound organelle; voltage-gated potassium channel complex
Molecular Function: potassium channel regulator activity; protein binding; protein complex scaffold; Ras guanyl-nucleotide exchange factor activity; receptor binding
Biological Process: G2/M transition of mitotic cell cycle; MAPKKK cascade; microtubule nucleation; positive regulation of peptidyl-serine phosphorylation; signal transduction; synaptic transmission; transport
Disease: Long Qt Syndrome 11
Research Articles on AKAP9
1. results support a model in which AKAP350 recruits CIP4 to the centrosome, providing a centrosomal scaffold to integrate microtubule and actin dynamics, thus enabling centrosome polarization and ensuring cell migration directionality.
Precautions
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Disclaimer
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