Product Name
CACNB2, Monoclonal Antibody
Full Product Name
CACNB2 (Calcium channel, voltage-dependent, beta 2 subunit, CAB2, CACNLB2, EA5, EJM, dihydropyridine-sensitive L-type)
Product Synonym Names
Anti -CACNB2 (Calcium channel, voltage-dependent, beta 2 subunit, CAB2, CACNLB2, EA5, EJM, dihydropyridine-sensitive L-type)
Product Gene Name
anti-CACNB2 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for A6PVM7
Species Reactivity
Human, Mouse, Rat
Specificity
Recognizes human CACNB2. Species crossreactivity: mouse and rat.
Purity/Purification
Affinity Purified
Purified by affinity chromatography.
Form/Format
Supplied as a lyophilized powder from PBS, pH 7.2. Reconstitute in 100ul of sterile H2O.
Immunogen
Partial recombinant protein of human CAB2 (aa 213-301) with a GST tag.
Preparation and Storage
Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with sterile 40-50% glycerol, ddH2O. Reconstituted product is stable for 12 months at -20 degree C. Aliquot and store at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Other Notes
Small volumes of anti-CACNB2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CACNB2 antibody
The L-type calcium channel is composed of four subunits: alpha-1, alpha-2, beta and gamma. The beta subunit of voltage-dependent calcium channels aids the function of the calcium channel by increasing the peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting. CAB2 is a membrane protein that is expressed in all tissues. The unprocessed precursor is 660 amino acids in length and has a predicted molecular weight of 74.5KDa. It belongs to the calcium channel beta subunit family and contains one SH3 domain. CAB2 is involved in the MAPK signalling pathway and is also associated with Lambert-Eaton myasthenic syndrome.
Product Categories/Family for anti-CACNB2 antibody
Antibodies; Abs to Ion Channel
Applications Tested/Suitable for anti-CACNB2 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-CACNB2 antibody
Suitable for use in Western Blot and ELISA.
Dilution: ELISA: 0.1ng/ml
Optimal dilution determined by the researcher.
NCBI/Uniprot data below describe general gene information for CACNB2. It may not necessarily be applicable to this product.
UniProt Primary Accession #
A6PVM7
[Other Products]
Molecular Weight
68,326 Da[Similar Products]
NCBI Official Full Name
calcium channel, voltage-dependent, beta 2 subunit
UniProt Protein Name
Calcium channel, voltage-dependent, beta 2 subunit
Protein Family
Voltage-dependent L-type calcium channel
UniProt Gene Name
CACNB2??[Similar Products]
UniProt Entry Name
A6PVM7_HUMAN
UniProt Comments for CACNB2
CACNB2: The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting. Defects in CACNB2 are the cause of Brugada syndrome type 4 (BRGDA4). A heart disease characterized by the association of Brugada syndrome with shortened QT intervals. Brugada syndrome is a tachyarrhythmia characterized by right bundle branch block and ST segment elevation on an electrocardiogram (ECG). It can cause the ventricles to beat so fast that the blood is prevented from circulating efficiently in the body. When this situation occurs (called ventricular fibrillation), the individual will faint and may die in a few minutes if the heart is not reset. Belongs to the calcium channel beta subunit family. 8 isoforms of the human protein are produced by alternative splicing.
Protein type: Channel, calcium
Chromosomal Location of Human Ortholog: 10p12
Cellular Component: integral to plasma membrane; voltage-gated calcium channel complex; sarcolemma
Molecular Function: voltage-gated calcium channel activity; protein binding; calcium channel activity; high voltage-gated calcium channel activity
Biological Process: axon guidance; synaptic transmission; visual perception; transport; positive regulation of calcium ion transport; neuromuscular junction development
Disease: Brugada Syndrome 4
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
