Full Product Name
Rabbit CBF beta Antibody
Product Synonym Names
CBF b
Product Gene Name
anti-CBF beta antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 16; NC_000016.9 (67063050..67134961). Location: 16q22.1
3D Structure
ModBase 3D Structure for Q13951
Species Reactivity
Human, mouse, rat
Form/Format
Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
Concentration
1 mg/ml (lot specific)
Other Notes
Small volumes of anti-CBF beta antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-CBF beta antibody
ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB)
NCBI/Uniprot data below describe general gene information for CBF beta. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001746.1
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NCBI GenBank Nucleotide #
NM_001755.2
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UniProt Primary Accession #
Q13951
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UniProt Secondary Accession #
Q13124; Q9HCT2; A8K347[Other Products]
UniProt Related Accession #
Q13951[Other Products]
Molecular Weight
21,508 Da
NCBI Official Full Name
core-binding factor subunit beta isoform 2
NCBI Official Synonym Full Names
core-binding factor, beta subunit
NCBI Official Symbol
CBFB??[Similar Products]
NCBI Official Synonym Symbols
PEBP2B
??[Similar Products]
NCBI Protein Information
core-binding factor subunit beta; CBF-beta; PEA2-beta; PEBP2-beta; SL3-3 enhancer factor 1 beta subunit; SL3-3 enhancer factor 1 subunit beta; SL3/AKV core-binding factor beta subunit; polyomavirus enhancer-binding protein 2 beta subunit; polyomavirus enhancer binding protein 2, beta subunit
UniProt Protein Name
Core-binding factor subunit beta
UniProt Synonym Protein Names
Polyomavirus enhancer-binding protein 2 beta subunit; PEA2-beta; PEBP2-beta; SL3-3 enhancer factor 1 subunit beta; SL3/AKV core-binding factor beta subunit
UniProt Gene Name
CBFB??[Similar Products]
UniProt Synonym Gene Names
CBF-beta; PEA2-beta; PEBP2-beta??[Similar Products]
UniProt Entry Name
PEBB_HUMAN
NCBI Summary for CBF beta
The protein encoded by this gene is the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family which master-regulates a host of genes specific to hematopoiesis (e.g., RUNX1) and osteogenesis (e.g., RUNX2). The beta subunit is a non-DNA binding regulatory subunit; it allosterically enhances DNA binding by alpha subunit as the complex binds to the core site of various enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers and GM-CSF promoters. Alternative splicing generates two mRNA variants, each encoding a distinct carboxyl terminus. In some cases, a pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript consisting of the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain 11. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for CBF beta
CBFB: CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM- CSF promoters. CBFB enhances DNA binding by RUNX1. A chromosomal aberration involving CBFB is associated with acute myeloid leukemia of M4EO subtype. Pericentric inversion inv(16)(p13;q22). The inversion produces a fusion protein that consists of the 165 N-terminal residues of CBF-beta (PEPB2) with the tail region of MYH11. Belongs to the CBF-beta family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Oncoprotein; DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 16q22.1
Cellular Component: membrane; nucleus
Molecular Function: protein binding; DNA binding; transcription coactivator activity; transcription factor activity
Biological Process: osteoblast differentiation; transcription from RNA polymerase II promoter; lymphocyte differentiation; cell maturation; myeloid cell differentiation; positive regulation of transcription from RNA polymerase II promoter
Research Articles on CBF beta
1. These separation-of-function mutants demonstrate that HIV-1 Vif and the RUNX transcription factors interact with cellular CBFbeta on genetically distinct surfaces.
Precautions
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Disclaimer
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